Martin Pamela S, Rodgers Cooper D, Fantin Aldo, Erdag Gulsun
University of Florida, 1600 SW Archer Rd, Gainesville, FL, 32608, USA.
North Florida / South Georgia Veterans Health System, 1601 SW Archer Rd., Gainesville, FL, 32608, USA.
Am J Ophthalmol Case Rep. 2022 Feb 18;26:101427. doi: 10.1016/j.ajoc.2022.101427. eCollection 2022 Jun.
To present the importance of considering conjunctival myxoid stromal tumors in the differential when evaluating eyelid lesions as these tumors could indicate undetected systemic syndromes including Zollinger-Ellison Syndrome, Carney complex, and other endocrine disorders.
We present the case of a 56-year-old Caucasian female who was evaluated for a solid cyst-like structure of the palpebral conjunctiva just temporal to, but not involving, the left lower eyelid punctum. The lesion was removed with histopathologic examination of the specimen revealing the lesion to be a myxoid spindle cell tumor, consistent with conjunctival myxoid stromal tumor.
Myxoid tumors are an abnormal proliferation of mesenchymal cells. These are most commonly found in the heart and less commonly in the bone, skin, and skeletal muscle. Myxoid tumors of the conjunctiva are a very rare reported finding and most reported cases involving the conjunctiva occur on the bulbar conjunctiva. Our patient was found to have a conjunctival myxoid stromal tumor of the palpebral conjunctiva. As these are rare lesions, we believe that considering this as a differential when evaluating eyelid margin lesions is important due to the association of these tumors with systemic conditions including Zollinger-Ellison Syndrome, Carney complex, and other Endocrine disorders.
阐述在评估眼睑病变时，将结膜黏液样间质肿瘤纳入鉴别诊断的重要性，因为这些肿瘤可能提示未被发现的全身综合征，包括卓-艾综合征、卡尼综合征和其他内分泌疾病。
我们报告了一例56岁的白种女性病例，该患者因左眼下睑泪小点颞侧但未累及泪小点的睑结膜实性囊肿样结构接受评估。病变被切除，标本的组织病理学检查显示病变为黏液样梭形细胞瘤，符合结膜黏液样间质肿瘤。
黏液样肿瘤是间充质细胞的异常增殖。这些肿瘤最常见于心脏，较少见于骨骼、皮肤和骨骼肌。结膜黏液样肿瘤是一种非常罕见的报告发现，大多数报告的累及结膜的病例发生在球结膜。我们的患者被发现患有睑结膜结膜黏液样间质肿瘤。由于这些是罕见病变，我们认为在评估睑缘病变时将其作为鉴别诊断很重要，因为这些肿瘤与包括卓-艾综合征、卡尼综合征和其他内分泌疾病在内的全身疾病有关。
