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结膜黏液瘤:一例罕见肿瘤的报告及文献复习。

Conjunctival myxoma: A case report and review of a rare tumor.

机构信息

Department of Ophthalmology, Chungbuk National University Hospital, Cheongju, Republic of Korea.

Department of Ophthalmology, Chungnam National University College of Medicine, Chungnam National University Hospital, Daejeon, Republic of Korea.

出版信息

Medicine (Baltimore). 2024 Mar 8;103(10):e37342. doi: 10.1097/MD.0000000000037342.

DOI:10.1097/MD.0000000000037342
PMID:38457580
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10919476/
Abstract

RATIONALE

Conjunctival myxoma is a rare benign tumor, which can mimic more common conjunctival lesions such as a cyst, lymphangioma, amelanotic nevus, neurofibroma, amelanotic melanoma, or lipoma. We describe a patient with the conjunctival myxoma, who was initially misdiagnosed as a conjunctival cyst. This case report includes intraoperative photographs and various immunohistochemical staining images.

PATIENTS CONCERNS

A 55-year-old woman presented with a painless mass in the superotemporal conjunctiva of the left eye, which she had noticed 1 month ago. The patient had no previous history of trauma or eye surgery. Slit-lamp examination revealed a well-circumscribed, freely movable, pinkish, semi-translucent mass on the temporal bulbar conjunctiva, suggestive of a conjunctival cyst.

DIAGNOSES

Histopathological analysis showed stellate- and spindle-shaped cells within the loose myxoid stroma, confirming a diagnosis of conjunctival myxoma.

INTERVENTIONS

The conjunctival lesion was completely excised under local anesthesia.

OUTCOMES

After 4 months of follow-up, the patient remained in good health without recurrence of the conjunctival lesion and no evidence of any systemic abnormality.

LESSONS

Myxoma is an extremely uncommon benign tumor derived from primitive mesenchyme. Considering the rarity of the tumor and its similarity to other conjunctival tumors, diagnosis can be challenging. Ophthalmologists should consider myxoma as a possible differential diagnosis when encountering conjunctival lesions. Surgical excision is essential to confirm the diagnosis and careful systemic evaluation is required to prevent potentially life-threatening underlying systemic conditions.

摘要

背景

结膜黏液瘤是一种罕见的良性肿瘤,可类似于更常见的结膜病变,如囊肿、淋巴管瘤、无色素性神经痣、神经纤维瘤、无色素性黑色素瘤或脂肪瘤。我们描述了一位结膜黏液瘤患者,该患者最初被误诊为结膜囊肿。本病例报告包括术中照片和各种免疫组织化学染色图像。

患者关注

一位 55 岁女性因左眼上方球结膜无痛性肿块就诊,1 个月前发现该肿块。患者无外伤或眼部手术史。裂隙灯检查显示颞侧球结膜有一个边界清楚、可自由移动的粉红色半透明肿块,提示结膜囊肿。

诊断

组织病理学分析显示在疏松黏液基质中有星状和梭形细胞,确诊为结膜黏液瘤。

干预措施

在局部麻醉下完全切除结膜病变。

结果

随访 4 个月后,患者身体健康,结膜病变无复发,无任何系统性异常证据。

教训

黏液瘤是一种源自原始间充质的非常罕见的良性肿瘤。考虑到肿瘤的罕见性及其与其他结膜肿瘤的相似性,诊断可能具有挑战性。当遇到结膜病变时,眼科医生应考虑黏液瘤作为可能的鉴别诊断。手术切除对于明确诊断至关重要,需要进行仔细的系统评估以预防潜在危及生命的系统性疾病。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3153/10919476/067fe7401bc7/medi-103-e37342-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3153/10919476/2f8f5c682059/medi-103-e37342-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3153/10919476/067fe7401bc7/medi-103-e37342-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3153/10919476/2f8f5c682059/medi-103-e37342-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3153/10919476/067fe7401bc7/medi-103-e37342-g002.jpg

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