镰状细胞性黄斑病变的结膜光学相干断层扫描血管造影成像
Conjunctival optical coherence tomography angiography imaging in sickle cell maculopathy.
作者信息
Mgboji Glory E, Cain Dennis, Scott Adrienne W
机构信息
Retina Division, Wilmer Eye Institute, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD, 21287, USA.
出版信息
Am J Ophthalmol Case Rep. 2022 Feb 16;26:101428. doi: 10.1016/j.ajoc.2022.101428. eCollection 2022 Jun.
PURPOSE
To compare conjunctival and macular manifestations of sickle cell anemia using optical coherence tomography angiography (OCTA).
OBSERVATIONS
OCTA imaging of the macula in two patients with HbSS and HbSC revealed areas of decreased vascular density, more prominent in the deep capillary plexus than in the superficial capillary plexus. Conjunctival OCTA of both affected patients revealed areas of reduced vascular density corresponding to the vascular abnormalities observed on slit lamp examination and prominent conjunctival flow voids when compared to an unaffected control.
CONCLUSIONSAND IMPORTANCE
OCTA allows for high resolution visualization of conjunctival findings present in sickle cell patients with macular vascular flow voids. Further studies are needed to explore the utility of conjunctival OCTA and the relationship between conjunctival and macular perfusion and systemic hemoglobinopathy.
目的
使用光学相干断层扫描血管造影（OCTA）比较镰状细胞贫血的结膜和黄斑表现。
观察结果
对两名HbSS和HbSC患者的黄斑进行OCTA成像，发现血管密度降低区域，在深层毛细血管丛中比在浅层毛细血管丛中更明显。两名受影响患者的结膜OCTA显示，与未受影响的对照相比，血管密度降低区域与裂隙灯检查中观察到的血管异常相对应，且结膜血流信号缺失明显。
结论与意义
OCTA能够高分辨率显示镰状细胞病患者黄斑血管血流信号缺失时出现的结膜表现。需要进一步研究以探索结膜OCTA的效用以及结膜和黄斑灌注与全身性血红蛋白病之间的关系。
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