OCTA 检测镰状细胞病患者的黄斑血管异常。
Macular Vascular Abnormalities Identified by Optical Coherence Tomographic Angiography in Patients With Sickle Cell Disease.
机构信息
Retina Division, Wilmer Eye Institute, Johns Hopkins School of Medicine, Baltimore, Maryland.
Retina Division, Wilmer Eye Institute, Johns Hopkins School of Medicine, Baltimore, Maryland2Retina Division, Department of Ophthalmology, Rajavithi Hospital, College of Medicine, Rangsit University, Bangkok, Thailand.
出版信息
JAMA Ophthalmol. 2015 Nov;133(11):1337-40. doi: 10.1001/jamaophthalmol.2015.2824.
IMPORTANCE
Patients with sickle cell disease may develop various macular vascular abnormalities that have not been described previously and can be seen using optical coherence tomographic angiography.
OBSERVATIONS
Ten eyes from 5 consecutive patients (3 men and 2 women) with sickle cell disease (4 patients with hemoglobin SS disease and 1 patient with hemoglobin SC disease) were included. The mean age was 37.6 years. Five of 10 eyes (50%) had retinal thinning that was identified using spectral-domain optical coherence tomography. Each of these eyes had corresponding loss of vascular density in the superficial or deep retinal plexus (or both).
CONCLUSIONS AND RELEVANCE
Optical coherence tomographic angiography provides a novel way to view the retinal vasculature, including the superficial and deep capillary plexus, and may provide a sensitive method for identifying macular vascular abnormalities in patients with sickle cell disease.
重要性
镰状细胞病患者可能会出现各种以前未描述过的黄斑血管异常，这些异常可以通过光相干断层扫描血管造影术观察到。
观察结果
连续 5 例镰状细胞病患者（3 名男性和 2 名女性）的 10 只眼（4 例血红蛋白 SS 病患者和 1 例血红蛋白 SC 病患者）纳入研究。患者平均年龄为 37.6 岁。10 只眼中有 5 只（50%）出现了视网膜变薄，这是通过频域光相干断层扫描发现的。这些眼中的每只眼的浅层或深层视网膜丛（或两者）都有相应的血管密度丧失。
结论和相关性
光相干断层扫描血管造影术为观察视网膜血管（包括浅层和深层毛细血管丛）提供了一种新方法，它可能为识别镰状细胞病患者的黄斑血管异常提供一种敏感的方法。
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