Cabrera-Mino Cristina, Roy Bhaswati, Woo Mary A, Freeby Matthew J, Kumar Rajesh, Choi Sarah E
UCLA School of Nursing, University of California Los Angeles, Los Angeles, CA.
Department of Anesthesiology, University of California Los Angeles, Los Angeles, CA.
Sleep Vigil. 2021 Dec;5(2):289-297. doi: 10.1007/s41782-021-00170-4. Epub 2021 Oct 4.
Poor sleep is common in adults with Type 2 Diabetes Mellitus (T2DM), which may contribute to brain tissue changes. However, the impact of sleep quality on brain tissue in T2DM individuals is unclear. We aimed to evaluate differential sleep quality with brain changes, and brain tissue integrity in T2DM patients.
Data were collected from 34 patients with T2DM and included sleep quality (assessed by the Pittsburgh Sleep Quality Index [PSQI], and high-resolution T1-weighted brain images using a 3.0-Tesla MRI scanner. Gray matter density (GMD) maps were compared between subjects with good vs poor sleep quality as assessed by PSQI (covariates: age, sex, BMI).
Of 34 T2DM patients, 17 showed poor sleep quality. Multiple brain sites, including the hippocampus, cerebellum, prefrontal, amygdala, thalamus, hypothalamus, insula, cingulate, and temporal areas, showed reduced gray matter in T2DM patients with poor sleep quality over patients with good sleep quality. Negative associations emerged between PSQI scores and gray matter density in multiple areas.
T2DM patients with poor sleep quality show brain tissue changes in sites involved in sleep regulation. Findings indicate that improving sleep may help mitigate brain tissue damage, and thus, improve brain function in T2DM patients.
睡眠质量差在2型糖尿病（T2DM）成人患者中很常见，这可能会导致脑组织变化。然而，睡眠质量对T2DM患者脑组织的影响尚不清楚。我们旨在评估T2DM患者不同的睡眠质量与脑变化以及脑组织完整性之间的关系。
收集了34例T2DM患者的数据，包括睡眠质量（通过匹兹堡睡眠质量指数[PSQI]评估），以及使用3.0特斯拉MRI扫描仪获得的高分辨率T1加权脑图像。比较了根据PSQI评估的睡眠质量良好与较差的受试者之间的灰质密度（GMD）图（协变量：年龄、性别、BMI）。
在34例T2DM患者中，17例睡眠质量较差。多个脑区，包括海马体、小脑、前额叶、杏仁核、丘脑、下丘脑、岛叶、扣带回和颞叶区域，睡眠质量较差的T2DM患者的灰质比睡眠质量良好的患者减少。PSQI评分与多个区域的灰质密度之间出现负相关。
睡眠质量差的T2DM患者在参与睡眠调节的脑区出现脑组织变化。研究结果表明，改善睡眠可能有助于减轻脑组织损伤，从而改善T2DM患者的脑功能。
