Michael G. DeGroote Institute for Infectious Disease Research, McMaster Immunology Research Centre, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada.
Michael G. DeGroote Institute for Infectious Disease Research, Health Research Methodology, Evidence, and Impact, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada.
Cell Rep Med. 2022 Feb 3;3(2):100509. doi: 10.1016/j.xcrm.2022.100509. eCollection 2022 Feb 15.
The induction of broadly neutralizing antibodies (bNAbs) that target the hemagglutinin stalk domain is a promising strategy for the development of "universal" influenza virus vaccines. bNAbs can be boosted in adults by sequential exposure to heterosubtypic viruses through natural infection or vaccination. However, little is known about if or how bNAbs are induced by vaccination in more immunologically naive children. Here, we describe the impact of repeated seasonal influenza vaccination and vaccine type on induction of bNAbs against group 1 influenza viruses in a pediatric cohort enrolled in randomized controlled trials of seasonal influenza vaccination. Repeated seasonal vaccination results in significant boosting of a durable bNAb response. Boosting of serological bNAb titers is comparable within inactivated and live attenuated (LAIV) vaccinees and declines with age. These data provide insights into vaccine-elicited bNAb induction in children, which have important implications for the design of universal influenza vaccine modalities in this critical population.
诱导针对血凝素茎域的广泛中和抗体（bnAbs）是开发“通用”流感病毒疫苗的一种有前途的策略。bnAbs 可以通过自然感染或接种使成人通过连续接触异源病毒而增强。然而，对于 bnAbs 是否以及如何通过接种在免疫原性更幼稚的儿童中诱导，知之甚少。在这里，我们描述了在接受季节性流感疫苗接种的随机对照试验中招募的儿科队列中，重复季节性流感疫苗接种和疫苗类型对诱导针对 1 组流感病毒的 bnAbs 的影响。重复季节性接种可显著增强持久的 bnAb 反应。灭活疫苗和减毒活疫苗（LAIV）接种者的血清学 bnAb 滴度增强相当，并且随年龄而下降。这些数据提供了对儿童中疫苗诱导的 bnAb 诱导的深入了解，这对在这一关键人群中设计通用流感疫苗模式具有重要意义。
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