Clinical Chemistry Department, CHU de Liège, Liège, Belgium.
Shriners Hospital for Children, McGill University, Montreal, Canada.
Calcif Tissue Int. 2023 Feb;112(2):218-232. doi: 10.1007/s00223-022-00964-2. Epub 2022 Mar 4.
Bone turnover markers (BTMs) have been developed many years ago to study, in combination with imaging techniques, bone remodeling in adults. In children and adolescents, bone metabolism differs from adults since it implies both growth and bone remodeling, suggesting an age- and gender-dependent BTM concentration. Therefore, specific studies have evaluated BTMs in not only physiological but also pathological conditions. However, in pediatrics, the use of BTMs in clinical practice is still limited due to these many children-related specificities. This review will discuss about physiological levels of BTMs as well as their modifications under pathological conditions in children and adolescents. A focus is also given on analytical and clinical challenges that restrain BTM usefulness in pediatrics.
骨转换标志物（BTMs）多年前被开发出来，用于结合影像学技术研究成年人的骨重塑。在儿童和青少年中，骨代谢与成年人不同，因为它既包括生长又包括骨重塑，提示 BTM 浓度与年龄和性别有关。因此，不仅在生理条件下，而且在病理条件下，都有专门的研究来评估 BTMs。然而，在儿科领域，由于涉及到许多儿童特有的因素，BTMs 的临床应用仍然有限。这篇综述将讨论 BTMs 的生理水平以及在儿童和青少年病理条件下的变化。此外，还重点讨论了限制 BTMs 在儿科应用的分析和临床挑战。
