Rempe Jakob, Rosengren Björn E, Jehpsson Lars, Swärd Per, Dencker Magnus, Karlsson Magnus K
Department of Orthopaedics, Helsingborg Hospital, Lund University, Helsingborg, Sweden.
Clinical and Molecular Osteoporosis Research Unit, Clinical Sciences, Lund University, Malmo, Sweden.
Acta Paediatr. 2025 May;114(5):944-953. doi: 10.1111/apa.17510. Epub 2024 Nov 21.
To analyse the association between bone turnover markers and bone mass in children and young adults.
This descriptive study followed 132 children (68 boys/64 girls) from Malmö, Sweden, as controls in a school-based intervention study (2000-2017). Height, weight, Tanner stage and bone mass were measured annually from ages 8 to 15 years, with follow-ups at 19 and 23 years of age. Serum markers for bone formation (bone-specific alkaline phosphatase (bALP), N-terminal propeptide of collagen type 1 (PINP), osteocalcin) and resorption (C-terminal telopeptide crosslinks (CTX), tartrate-resistant acid phosphatase (TRAcP 5b)) were collected at ages 9.9 ± 0.6 (mean ± SD) (n = 78), 12.0 ± 0.6 (n = 64), 14.9 ± 0.8 (n = 52), 18.8 ± 0.3 (n = 34) and 23.3 ± 0.6 years (n = 56).
Compared to girls, boys showed higher bone turnover markers at ages 15, 19 and 23 years (all p < 0.05). At 10 years of age (Tanner stage 1 and 2), bALP and TRAcP 5b correlated with current bone mass (adjusted for age and sex), while bALP, PINP, osteocalcin and CTX correlated with bone mass change over the next 2 years (adjusted for age, sex and interval) (all p < 0.05).
Bone turnover markers in early Tanner stages predicted both current bone mass and subsequent bone mass changes.
分析儿童和青年骨转换标志物与骨量之间的关联。
这项描述性研究追踪了来自瑞典马尔默的132名儿童（68名男孩/64名女孩），作为一项基于学校的干预研究（2000 - 2017年）的对照组。从8岁至15岁每年测量身高、体重、坦纳分期和骨量，并在19岁和23岁时进行随访。在9.9±0.6（均值±标准差）岁（n = 78）、12.0±0.6岁（n = 64）、14.9±0.8岁（n = 52）、18.8±0.3岁（n = 34）和23.3±0.6岁（n = 56）时采集骨形成（骨特异性碱性磷酸酶（bALP）、I型胶原N端前肽（PINP）、骨钙素）和骨吸收（C端交联肽（CTX）、抗酒石酸酸性磷酸酶（TRAcP 5b））的血清标志物。
与女孩相比，男孩在15岁、19岁和23岁时骨转换标志物更高（所有p < 0.05）。在10岁（坦纳分期1和2）时，bALP和TRAcP 5b与当前骨量相关（校正年龄和性别），而bALP、PINP、骨钙素和CTX与接下来2年的骨量变化相关（校正年龄、性别和时间间隔）（所有p < 0.05）。
坦纳早期的骨转换标志物可预测当前骨量和随后的骨量变化。
