Riches D W, Henson P M
Ann N Y Acad Sci. 1986;465:6-14. doi: 10.1111/j.1749-6632.1986.tb18475.x.
The theme we have presented herein is that of the adaptability of the mononuclear phagocyte. This has been illustrated by discussing the mechanisms underlying the emigration of blood monocytes into peripheral tissues and organs under steady state and inflammatory conditions. Our basic tenet is that monocytes represent a relatively homogeneous cell population which migrates, either randomly or selectively, into a tissue and matures, following interaction with tissue components (be they normal or inflammatory), into macrophages characteristic of that tissue. Thus it is the interaction of a mononuclear phagocyte with an inflammatory stimulus that directs the phagocyte to mature into an inflammatory macrophage. Finally, we have also discussed how stimulus impingement on macrophages influences the products these cells secrete. We conclude that macrophages are essential to both the degradative and remodeling phases of an inflammatory response.
我们在此提出的主题是单核吞噬细胞的适应性。通过讨论在稳态和炎症条件下血液单核细胞迁移到外周组织和器官的潜在机制，这一点得到了说明。我们的基本宗旨是，单核细胞代表相对同质的细胞群体，它们随机或选择性地迁移到组织中，并在与组织成分（无论是正常的还是炎症性的）相互作用后成熟为该组织特有的巨噬细胞。因此，正是单核吞噬细胞与炎症刺激的相互作用引导吞噬细胞成熟为炎症巨噬细胞。最后，我们还讨论了刺激对巨噬细胞的影响如何影响这些细胞分泌的产物。我们得出结论，巨噬细胞对于炎症反应的降解和重塑阶段都是必不可少的。
