Department of Radiation Oncology, Miami Cancer Institute, Baptist Health South Florida, Miami, Florida, USA.
Office of Clinical Research, Miami Cancer Institute, Baptist Health South Florida, Miami, Florida, USA.
Head Neck. 2022 May;44(5):1213-1222. doi: 10.1002/hed.27021. Epub 2022 Mar 4.
Submandibular gland (SMG) transfer decreased radiation-associated xerostomia in the 2/3-dimensional radiotherapy era. We evaluated the dosimetric implications of SMG transfer on modern intensity modulated radiotherapy (IMRT) plans.
Eighteen oropharynx cancer patients underwent SMG transfer followed by IMRT; reoptimized plans using the baseline SMG location were generated. Mean salivary gland, oral cavity, and larynx doses were compared between clinical plans and reoptimized plans.
No statistically significant difference in mean SMG dose (27.53 Gy vs. 29.61 Gy) or total salivary gland dose (26.12 Gy vs. 26.41 Gy) was observed with or without SMG transfer (all p > 0.05). Mean oral cavity and larynx doses were not statistically different. Neither tumor site, target volume crossing midline, stage, nor salivary gland volumes were associated with mean doses.
Salivary gland doses were similar with or without SMG transfer. IMRT likely decreases the benefit of SMG transfer on the risk of radiation-associated xerostomia.
在二维和三维放疗时代，下颌下腺（SMG）转移可减少放疗相关性口干。我们评估了 SMG 转移对现代调强放疗（IMRT）计划的剂量学影响。
18 例口咽癌患者接受 SMG 转移后行 IMRT；基于基线 SMG 位置重新优化了计划。比较了临床计划和重新优化计划中唾液腺、口腔和喉部的平均剂量。
无论是否进行 SMG 转移，SMG 的平均剂量（27.53Gy 比 29.61Gy）或总唾液腺剂量（26.12Gy 比 26.41Gy）均无统计学差异（均 P＞0.05）。口腔和喉部的平均剂量无统计学差异。肿瘤部位、靶区穿过中线、分期或唾液腺体积均与平均剂量无关。
有无 SMG 转移，唾液腺剂量相似。IMRT 可能降低了 SMG 转移对放疗相关性口干风险的获益。
