IRCCS Centro Neurolesi "Bonino-Pulejo", S.S. 113, Via Palermo, C. da Casazza, 98124 Messina, Italy.
Medicine (Baltimore). 2022 Mar 4;101(9):e28922. doi: 10.1097/MD.0000000000028922.
Idiopathic normal pressure hydrocephalus (NPH) is a syndrome that affects elderly people and is characterized by excessive accumulation of cerebrospinal fluid in the brain ventricles. Diagnosis is based on the evaluation of clinical symptoms, which consists of a classic triad (Hakim triad), gait disturbances, cognitive impairment, and urinary incontinence. However, this complete triad is not always seen; therefore, it is difficult to make the diagnosis. NPH can be divided into primary or idiopathic NPH and secondary NPH. Diagnostic criteria for NPH remain a topic of discussion; however, the development of diagnostic techniques has brought new opportunities for diagnosis. The aim of this review is to present an overview of neurophysiological and neuropsychological approaches to support the clinical evaluation of patients with NPH and contribute to the differential diagnosis of NPH and dementia, as the clinical symptoms of NPH may resemble other neurodegenerative disorders.
特发性正常压力脑积水(NPH)是一种影响老年人的综合征,其特征是脑室内脑脊液过度积聚。诊断基于临床症状的评估,包括经典三联征(Hakim 三联征)、步态障碍、认知障碍和尿失禁。然而,并非总是出现完整的三联征,因此,难以做出诊断。NPH 可分为原发性或特发性 NPH 和继发性 NPH。NPH 的诊断标准仍存在争议;然而,诊断技术的发展为诊断带来了新的机会。本文旨在综述神经生理学和神经心理学方法,以支持 NPH 患者的临床评估,并有助于 NPH 和痴呆的鉴别诊断,因为 NPH 的临床症状可能类似于其他神经退行性疾病。