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中年患者正常压力脑积水的早期表现与管理:一例报告

Early Presentation and Management of Normal Pressure Hydrocephalus in a Middle-Aged Patient: A Case Report.

作者信息

Ogbu Chukwuemeka E, Oo Shoon L, Gupta Anjali, Doad Jagroop, Ezechukwu Maureen, Medina Yasier, Onyeaso Elizabeth

机构信息

Internal Medicine, Cape Fear Valley Health, Fayetteville, USA.

Medicine, Campbell University School of Osteopathic Medicine, Lillington, USA.

出版信息

Cureus. 2025 Aug 11;17(8):e89838. doi: 10.7759/cureus.89838. eCollection 2025 Aug.

Abstract

Normal pressure hydrocephalus (NPH) is an uncommon neurological disorder that is most often seen in adults over 60 years of age. Its pathogenesis remains uncertain but is believed to involve impaired cerebrospinal fluid (CSF) absorption, increased resistance to CSF outflow, or a mismatch between CSF production and resorption. Reports of NPH in patients younger than 60 are rare, as advanced age is closely associated with the condition. We describe a 55-year-old woman who presented to the emergency department with progressive ataxia, cognitive slowing, and urinary incontinence. Brain imaging demonstrated ventriculomegaly consistent with NPH, and she underwent continuous lumbar drainage with marked clinical improvement. She subsequently participated in an inpatient rehabilitation program, which resulted in further gains in mobility and cognition. Our case highlights the importance of considering NPH in middle-aged patients presenting with compatible symptoms and imaging findings, as timely intervention can lead to meaningful recovery.

摘要

正常压力脑积水(NPH)是一种罕见的神经系统疾病,多见于60岁以上的成年人。其发病机制尚不确定,但据信与脑脊液(CSF)吸收受损、脑脊液流出阻力增加或脑脊液生成与吸收不匹配有关。60岁以下患者中NPH的报告很少见,因为高龄与该疾病密切相关。我们描述了一名55岁女性,她因进行性共济失调、认知迟缓及尿失禁就诊于急诊科。脑部影像学显示脑室扩大,符合NPH表现,她接受了持续腰大池引流,临床症状明显改善。随后她参加了住院康复项目,在活动能力和认知方面进一步改善。我们的病例强调了对于出现相符症状和影像学表现的中年患者考虑NPH的重要性,因为及时干预可带来显著恢复。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c91a/12422828/2835765b3302/cureus-0017-00000089838-i01.jpg

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