Faculty of Medicine, 27964Pontificia Universidad Javeriana, Bogotá, DC, Colombia.
Internal Medicine Specialist and Pulmonologist, 173049Hospital Universitario San Ignacio, Bogotá, DC, Colombia.
Lupus. 2022 Apr;31(4):495-499. doi: 10.1177/09612033221084519. Epub 2022 Mar 4.
The coexistence of systemic lupus erythematosus (SLE) and ANCA-associated vasculitis (AAV) as an overlapping syndrome is not common. Here, we report a case of a 33-year-old woman, with recent SLE diagnosis due to skin, kidney, articular, and immunologic compromise, in whom a chest CT scan showed bilateral nodules, consolidations, and tree-in-bud pattern; thoracoscopic lung biopsy revealed diffuse non-caseating granulomas, without other features of sarcoid, organizing pneumonia, or hypersensitivity pneumonitis with high positive p-ANCA titers. Overlap between SLE and AAV was a possible explanation for lupus granulomatous pneumonitis, and for this reason, a multidisciplinary meeting was held to evaluate complex patients with interstitial lung diseases patients.
红斑狼疮（SLE）和抗中性粒细胞胞浆抗体（ANCA）相关性血管炎（AAV）重叠综合征并不常见。本文报告了一例 33 岁女性患者，因皮肤、肾脏、关节和免疫功能障碍而新近诊断为 SLE，胸部 CT 扫描显示双侧结节、实变和树芽征；胸腔镜肺活检显示弥漫性非坏死性肉芽肿，无结节病、机化性肺炎或过敏性肺炎的其他特征，p-ANCA 滴度高。SLE 和 AAV 之间的重叠可能是狼疮性肉芽肿性肺炎的原因，因此，为评估间质性肺病患者，召开了多学科会议。
