用于检测循环肿瘤细胞的 GLUTs/GSH 级联靶向响应型生物探针。

A GLUTs/GSH cascade targeting-responsive bioprobe for the detection of circulating tumor cells.

机构信息

Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling, Shaanxi 712100, P. R. China.

出版信息

Chem Commun (Camb). 2022 Mar 22;58(24):3945-3948. doi: 10.1039/d2cc00566b.

DOI:10.1039/d2cc00566b

PMID:35244637

Abstract

A GLUTs/GSH cascade targeting-responsive bioprobe, GluCC, was rationally designed and synthesized for the first time the coordination of copper ions with a glucose-modified coumarin derivative ligand (GluC). GluCC can specifically detect circulating tumor cells (CTCs) in lung metastatic mice models by targeting the Warburg effect and responding to overexpressed glutathione in the tumor microenvironment. This bioprobe with a simple detection procedure has significant advantages for CTC detection.

摘要

首次设计并合成了 GLUTs/GSH 级联靶向响应型生物探针 GluCC，该探针通过与葡萄糖修饰的香豆素衍生物配体（GluC）配位来特异性识别具有沃伯格效应的循环肿瘤细胞（CTCs），并响应肿瘤微环境中过表达的谷胱甘肽。这种生物探针具有简单的检测程序，在 CTC 检测方面具有显著优势。