Pharmaceutical Analysis Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Food and Drug Safety Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Pharmaceutical Analysis Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Biomed Pharmacother. 2021 Feb;134:111153. doi: 10.1016/j.biopha.2020.111153. Epub 2020 Dec 24.
Cancer metastasis is one of the foremost causes of cancer incidence and fatality in the whole of the world. Circulating tumor cells (CTC) have been confirmed to be among the most significant stimuli of metastasis in recent years and presently are the subject of extensive research aiming to be accurately identified by using biological and physical properties. Among the various studies conducted for isolation, identification, and characterization of CTCs, microfluidic systems have aroused great attention owing to their unique advantages such as low-cost, simplicity, reduction in reagent consumption, miniaturization, fast and precise control. The purpose of this review is to provide an overview of current state of the microfluidic biosensors for the screening of CTCs. Additionally, given the recent progress in this field, future outlook for the development of the microfluidics biosensing is briefly discussed.
癌症转移是全世界癌症发病率和死亡率的首要原因之一。近年来，循环肿瘤细胞（CTC）已被证实是转移的最重要刺激因素之一，目前正在进行广泛的研究，旨在利用生物和物理特性准确识别它们。在用于分离、鉴定和表征 CTC 的各种研究中，微流控系统因其低成本、简单、减少试剂消耗、小型化、快速精确控制等独特优势而引起了极大的关注。本综述的目的是概述用于筛选 CTC 的微流控生物传感器的最新研究进展。此外，鉴于该领域的最新进展，简要讨论了微流控生物传感的未来发展前景。
