Hedman P, Rombo L, Björkman A, Brohult J, Kihamia C M, Potter J, Stenbeck J
Ann Trop Med Parasitol. 1986 Feb;80(1):7-11. doi: 10.1080/00034983.1986.11811979.
The in vivo response of Plasmodium falciparum to chloroquine and to pyrimethamine/sulfadoxine was studied for seven days in schoolchildren from two villages 30 to 40 km north of Dar es Salaam. Standard therapeutic regimen of chloroquine (25 mg base kg-1) failed to clear parasitaemia in 17 of 62 (27%) treated subjects. In contrast, standard treatment with pyrimethamine/sulfadoxine cleared the parasitaemia in all 44 treated subjects within five days. Hence, in the studied area, the therapeutic effect of sulfadoxine/pyrimethamine was superior to that of chloroquine.
