在坦桑尼亚六个已检测到对氯喹耐药的恶性疟原虫的地区，对恶性疟原虫对磺胺多辛/乙胺嘧啶合剂（Fansidar）的敏感性进行体内评估。

In vivo assessment of the sensitivity of Plasmodium falciparum to sulphadoxine/pyrimethamine combination (Fansidar) in six localities in Tanzania where chloroquine-resistant P. falciparum has been detected.

作者信息

Kilimali V A, Mkufya A R

出版信息

Trans R Soc Trop Med Hyg. 1985;79(4):482-3. doi: 10.1016/0035-9203(85)90071-9.

Abstract

The sensitivity of Plasmodium falciparum strains to Fansidar (500 mg sulphadoxine/25 mg pyrimethamine) was tested in vivo in six localities in the United Republic of Tanzania where chloroquine-resistant P. falciparum strains have been demonstrated by both in vivo and in vitro tests. Single doses as recommended by the manufacturers achieved 100% clearance of parasitaemia in five localities with mean clearance period of between 2.2 and 2.9 days. In one locality (Gonja) the recommended dose failed to clear parasitaemia in two of the 38 cases (5.3%) within seven days. The possibility of using this drug combination for the treatment of chloroquine-resistant P. falciparum strains in the United Republic of Tanzania is discussed.

摘要

在坦桑尼亚联合共和国的六个地区对恶性疟原虫菌株对Fansidar（500毫克周效磺胺/25毫克乙胺嘧啶）的敏感性进行了体内测试，在这些地区，体内和体外测试均已证明存在对氯喹耐药的恶性疟原虫菌株。按照制造商推荐的单剂量给药，在五个地区实现了100%的疟原虫血症清除率，平均清除期在2.2至2.9天之间。在一个地区（贡贾），38例病例中有2例（5.3%）在七天内未实现疟原虫血症清除。文中讨论了在坦桑尼亚联合共和国使用这种药物组合治疗对氯喹耐药的恶性疟原虫菌株的可能性。