Department of Basic and Translational Sciences, Penn Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Periodontol 2000. 2022 Jun;89(1):9-18. doi: 10.1111/prd.12430. Epub 2022 Mar 4.
Periodontitis, a microbiome-driven inflammatory disease of the tooth-attachment apparatus, is epidemiologically linked with other disorders, including cardio-metabolic, cognitive neurodegenerative and autoimmune diseases, respiratory infections, and certain cancers. These associations may, in part, be causal, as suggested by interventional studies showing that local treatment of periodontitis reduces systemic inflammation and surrogate markers of comorbid diseases. The potential cause-and-effect connection between periodontitis and comorbidities is corroborated by studies in preclinical models of disease, which additionally provided mechanistic insights into these associations. This overview discusses recent advances in our understanding of the periodontitis-systemic disease connection, which may potentially lead to innovative therapeutic options to reduce the risk of periodontitis-linked comorbidities.
牙周炎是一种由微生物群驱动的牙齿附着器官炎症性疾病，在流行病学上与其他疾病有关，包括心血管代谢、认知神经退行性和自身免疫性疾病、呼吸道感染和某些癌症。这些关联可能部分是因果关系，这一点可以从干预性研究中得到证实，这些研究表明，局部治疗牙周炎可以减轻全身炎症和合并症的替代标志物。在疾病的临床前模型中进行的研究进一步为这些关联提供了机制上的见解，也证实了牙周炎和合并症之间潜在的因果关系。这篇综述讨论了我们对牙周炎与系统性疾病联系的理解的最新进展，这可能会为减少与牙周炎相关的合并症的风险提供创新的治疗选择。
