OBJECTIVES: This study aims to perform a comprehensive bibliometric analysis of research on orthodontic treatment for patients with periodontal disease. By examining publication trends, citation patterns, and research hotspots, we seek to understand the evolution of this field, identify future trends, and promote an integrated approach to enhance treatment outcomes and patient care. METHODS: A comprehensive literature search was performed using the Web of Science and PubMed databases with the keywords "periodontal disease" "periodontology" "periodontitis" and "orthodontics".The retrieved records were systematically analyzed and visualized utilizing CiteSpace 6.2 and VOSviewer software. Bibliometric analysis was conducted across multiple dimensions, including authorship, geographic distribution (countries and institutions), keyword trends, and citation patterns in relevant journals. RESULTS: After screening titles, abstracts, and keywords, a total of 580 articles met the inclusion criteria for further analysis. The leading publishing countries were China and USA with significant contributions from Grigore T. Popa University of Medicine & Pharmacy. Ionuț Luchian emerged as the most prolific author, while Ainamo J. demonstrated considerable influence based on citation metrics. Authoritative journals, such as the American Journal of Orthodontics and Dentofacial Orthopedics, were identified as the most frequently cited publications in this field. CONCLUSIONS: Future research in orthodontic treatment for patients with periodontal disease is expected to focus on developing personalized treatment plans, utilizing innovative biomaterials, designing advanced biomarkers and predictive models, integrating regenerative medicine approaches, and comprehensively assessing patients' overall quality of life. These directions aim to enhance treatment efficacy, improve patient outcomes, and ensure a more holistic and individualized approach to care.