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科瓦克辛(Covaxin)与其他 COVID-19 疫苗的安全性和有效性的对比分析:综述。

A comparative analysis on the safety and efficacy of Covaxin versus other vaccines against COVID-19: a review.

机构信息

Department of Pharmacology, Girijananda Chowdhury Institute of Pharmaceutical Science, Guwahati 781017, India.

出版信息

Z Naturforsch C J Biosci. 2022 Mar 2;77(7-8):351-362. doi: 10.1515/znc-2021-0301. Print 2022 Jul 26.

Abstract

Since the identification of the genomic sequence of SARS-CoV-2, an unprecedented effort is being made until this date for the development of a safe and effective vaccine by pharma companies and laboratories worldwide. To attain herd immunity and quite possibly recover from this pandemic, which has claimed the life of about 4.23 million people, an exceptional effort has been made by the scientific community for the development of a vaccine. Various vaccines have been developed based on different platforms and each of them seems to possess its own merits and demerits based on its safety, immunogenicity, the durability of immunity, dosing schedule, technological platform, and ease of manufacture and transport. Based on these parameters this review aims to critically assess the efficacy of Covaxin and compare it with other vaccines in the WHO EUL list and perform a comparative analysis of COVID-19 vaccines which are in phase 3 and phase 4 of clinical trials. This will help us determine where COVAXIN stands against other vaccines and vaccine candidates based on these parameters which will ultimately help us determine the best vaccine that could potentially eradicate the COVID-19 pandemic.

摘要

自 SARS-CoV-2 基因组序列被鉴定以来,全球的制药公司和实验室一直在做出前所未有的努力,以开发安全有效的疫苗。为了获得群体免疫并有可能从这场已经夺走约 423 万人生命的大流行中恢复过来,科学界为开发疫苗做出了非凡的努力。已经基于不同平台开发了各种疫苗,根据其安全性、免疫原性、免疫持久性、剂量方案、技术平台以及制造和运输的便利性,每种疫苗似乎都有其自身的优缺点。基于这些参数,本综述旨在对 Covaxin 的疗效进行批判性评估,并将其与世界卫生组织 EUL 清单中的其他疫苗进行比较,并对处于临床试验第 3 阶段和第 4 阶段的 COVID-19 疫苗进行比较分析。这将帮助我们根据这些参数确定 COVAXIN 相对于其他疫苗和候选疫苗的位置,最终帮助我们确定最有可能根除 COVID-19 大流行的最佳疫苗。

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