Roll F J, Bissell D M, Perez H D
Biochem Biophys Res Commun. 1986 Jun 13;137(2):688-94. doi: 10.1016/0006-291x(86)91133-2.
When human hepatocytes were incubated with low concentrations of ethanol they general chemotactic activity for human neutrophils. Generation of chemotactic activity was dependent upon duration of incubation and concentration of ethanol used. Production of chemotactic activity by ethanol-treated hepatocytes was inhibited completely in the presence of the alcohol dehydrogenase inhibitor 4-methylpyrazole. PMN isolated from rats, in contrast, do not respond chemotactically to the factor released by homologous cells. Preliminary studies indicated that the chemotactic factor is non-polar in nature (perhaps related to leukotriene B4). These results indicate that human hepatocytes, when exposed to ethanol, generate chemotactic factor(s) for human PMN. The occurrence of this phenomenon may explain, in part, the PMN infiltrates observed in human liver during the course of acute alcoholic hepatitis.
当用人肝细胞与低浓度乙醇孵育时，它们会产生针对人中性粒细胞的趋化活性。趋化活性的产生取决于孵育时间和所用乙醇的浓度。在存在乙醇脱氢酶抑制剂4-甲基吡唑的情况下，经乙醇处理的肝细胞产生的趋化活性被完全抑制。相比之下，从大鼠分离的PMN对同源细胞释放的因子没有趋化反应。初步研究表明，趋化因子本质上是非极性的（可能与白三烯B4有关）。这些结果表明，人肝细胞在接触乙醇时会产生针对人PMN的趋化因子。这种现象的发生可能部分解释了在急性酒精性肝炎病程中人类肝脏中观察到的PMN浸润。
