Prazeres Juliana, Lucatto Luiz Filipe, Ferreira Adriano, Moraes Nilva, Braga Josefina A P, Lima Luiz H, Regatieri Caio, Maia Maurício
Department of Ophthalmology, Federal University of São Paulo, 806, Botucatu Street, São Paulo, 04026-062, Brazil.
Department of Pediatrics, Federal University of São Paulo, São Paulo, Brazil.
Int J Retina Vitreous. 2022 Mar 4;8(1):15. doi: 10.1186/s40942-021-00351-3.
To measure the retinal/choroidal thicknesses in the macular area of asymptomatic pediatric patients with sickle cell disease (SCD).
This cross-sectional cohort study included 40 children (79 eyes) with SCD and 19 control patients (36 eyes). All subjects underwent spectral-domain optical coherence tomography (SD-OCT) with enhanced-depth imaging OCT. Generalized Estimating Equations (GEE) were applied to compare the outcomes between groups. P ≤ 0.05 was considered significant.
The choroidal thickness in the macular area in the study subfields was significantly thinner in the SCD eyes compared with control eyes (subfoveal subfield and temporal parafoveal subfield, p < 0.0001; nasal parafoveal subfield, p < 0.0001 temporal perifoveal subfield, p < 0.0001; and nasal perifoveal subfield, p < 0.0001). The variations in the retinal thickness were not significant.
EDI-OCT showed that the macular choroidal thickness is thinner in asymptomatic pediatric patients with SCD.
测量无症状镰状细胞病（SCD）患儿黄斑区的视网膜/脉络膜厚度。
这项横断面队列研究纳入了40例患有SCD的儿童（79只眼）和19例对照患者（36只眼）。所有受试者均接受了具有增强深度成像功能的光谱域光学相干断层扫描（SD-OCT）。采用广义估计方程（GEE）比较组间结果。P≤0.05被认为具有统计学意义。
与对照眼相比，研究亚组中SCD眼黄斑区的脉络膜厚度明显更薄（中心凹下亚组和颞侧旁中心凹亚组，p<0.0001；鼻侧旁中心凹亚组，p<0.0001；颞侧中心凹周围亚组，p<0.0001；鼻侧中心凹周围亚组，p<0.0001）。视网膜厚度的差异不显著。
增强深度成像光学相干断层扫描（EDI-OCT）显示，无症状SCD患儿的黄斑脉络膜厚度更薄。
