门诊成人胰腺和胃食管癌症患者静脉血栓栓塞预测模型：系统评价和荟萃分析的方案。

Prediction models for venous thromboembolism in ambulatory adults with pancreatic and gastro-oesophageal cancer: protocol for systematic review and meta-analysis.

机构信息

Prehab, Activity, Cancer, Exercise and Survivorship (PACES) research Group, University of Canberra Faculty of Health, Canberra, Australian Capital Territory, Australia.

Faculty of Health, University of Canberra, Bruce, Australian Capital Territory, Australia.

出版信息

BMJ Open. 2022 Mar 4;12(3):e056431. doi: 10.1136/bmjopen-2021-056431.

DOI:10.1136/bmjopen-2021-056431

PMID:35246422

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8900042/

Abstract

INTRODUCTION

Venous thromboembolism (VTE) is a common complication of cancer. Pancreatic and gastro-oesophageal cancers are among malignancies that have the highest rates of VTE occurrence. VTE can increase cancer-related morbidity and mortality and disrupt cancer treatment. The risk of VTE can be managed with measures such as using anticoagulant drugs, although the risk of bleeding may be an impeding factor. Therefore, a VTE risk assessment should be performed before the start of anticoagulation in individual patients. Several prediction models have been published, but most of them have low sensitivity and unknown clinical applicability in pancreatic or gastro-oesphageal cancers. We intend to do this systematic review to identify all applicable published predictive models and compare their performance in those types of cancer.

METHODS AND ANALYSIS

All studies in which a prediction model for VTE have been developed, validated or compared using adult ambulatory patients with pancreatic or gastro-oesphageal cancers will be identified and the reported predictive performance indicators will be extracted. Full text peer-reviewed journal articles of observational or experimental studies published in English will be included. Five databases (Medline, EMBASE, Web of Science, CINAHL and Cochrane) will be searched. Two reviewers will independently undertake each of the phases of screening, data extraction and risk of bias assessment. The quality of the selected studies will be assessed using Prediction model Risk Of Bias Assessment Tool. The results from the review will be used for a narrative information synthesis, and if the same models have been validated in multiple studies, meta-analyses will be done to pool the predictive performance measures.

ETHICS AND DISSEMINATION

There is no need for ethics approval because the review will use previously peer-reviewed articles. The results will be published.

PROSPERO REGISTRATION NUMBER

CRD42021253887.

摘要

简介

静脉血栓栓塞症（VTE）是癌症的常见并发症。胰腺癌和胃食管腺癌等恶性肿瘤的 VTE 发生率最高。VTE 会增加癌症相关发病率和死亡率，并会干扰癌症治疗。可以使用抗凝药物等措施来管理 VTE 风险，尽管出血风险可能是一个阻碍因素。因此，应在开始抗凝治疗之前对每位患者进行 VTE 风险评估。已经发表了几种预测模型，但大多数模型在胰腺癌或胃食管腺癌中灵敏度较低，临床适用性未知。我们旨在进行这项系统评价，以确定所有适用的已发表预测模型，并比较它们在这些类型癌症中的性能。

方法和分析

将确定所有已开发、验证或比较过 VTE 预测模型的研究，这些研究使用的是患有胰腺癌或胃食管腺癌的成年门诊患者，并将提取报告的预测性能指标。将纳入发表在英文期刊上的观察性或实验性研究的全文同行评审文章。将搜索五个数据库（Medline、EMBASE、Web of Science、CINAHL 和 Cochrane）。两位审查员将独立进行筛选、数据提取和偏倚风险评估的各个阶段。将使用预测模型风险偏倚评估工具评估所选研究的质量。将对综述结果进行叙述性信息综合，如果相同的模型已在多项研究中得到验证，则将进行荟萃分析以汇总预测性能指标。