Awana Philippe Armel, Danwang Celestin, Tochie Joel Noutakdie, Bigna Jean Joel
Department of Radiology, Jamot Hospital, Yaoundé, Cameroon.
Institute of Experimental and Clinical Research, Université Catholique de Louvain, Bruxelles, Belgium
BMJ Open. 2019 Nov 12;9(11):e031402. doi: 10.1136/bmjopen-2019-031402.
In recent years, a hypothesis has been raised that people with tuberculosis are at risk for developing venous thromboembolism (VTE). However, much remains to be understood about the interplay between VTE and tuberculosis. Therefore, through a global systematic review and meta-analysis, the current study aims at investigating the association between exposure to active tuberculosis and risk of VTE, and determining the prevalence and incidence of VTE in people with active tuberculosis.
We will include cohort studies, case-control and cross-sectional studies performed among adults (>15 years) with active tuberculosis. EMBASE, Medline, Global Index Medicus and Web of Knowledge will be searched for relevant records published until 31 August 2019, without any language restriction. The review will be reported according to the Meta-analysis Of Observational Studies in Epidemiology guidelines. After screening of titles and abstracts, study selection, data extraction and risk of bias assessment; we shall assess the studies individually for clinical and statistical heterogeneity. Random-effect meta-analysis will be used to pool studies judged to be clinically homogenous. The Egger's test and visual inspection of funnel plots will be used to assess publication bias. Results will be presented by country and region.
Since primary data are not collected in this study, ethical approval is not required. This review is expected to provide relevant data on the epidemiology of VTE in people with tuberculosis. The final report will be published in a peer-reviewed journal.
CRD42019130347.
近年来，有人提出结核病患者有发生静脉血栓栓塞（VTE）的风险。然而，关于VTE与结核病之间的相互作用仍有许多有待了解之处。因此，通过一项全球系统评价和荟萃分析，本研究旨在调查活动性结核病暴露与VTE风险之间的关联，并确定活动性结核病患者中VTE的患病率和发病率。
我们将纳入针对成年（>15岁）活动性结核病患者开展的队列研究、病例对照研究和横断面研究。将检索EMBASE、Medline、全球医学索引和科学网，以获取截至2019年8月31日发表的相关记录，无任何语言限制。本评价将根据流行病学观察性研究的荟萃分析指南进行报告。在筛选标题和摘要、选择研究、提取数据和评估偏倚风险之后；我们将分别评估各项研究的临床和统计异质性。将采用随机效应荟萃分析来汇总判断为临床同质的研究。将使用Egger检验和漏斗图的直观检查来评估发表偏倚。结果将按国家和地区呈现。
由于本研究未收集原始数据，因此无需伦理批准。本评价预计将提供有关结核病患者VTE流行病学的相关数据。最终报告将发表在同行评审期刊上。
PROSPERO注册号：CRD42019130347。
