Department of Head and Neck Surgery, David Geffen School of Medicine, University of California, 10833 Le Conte Ave, 62-132 CHS, Los Angeles, CA, 9009, USA.
Department of Bioengineering, University of California Los Angeles, Los Angeles, CS, USA.
Sci Rep. 2022 Mar 4;12(1):3592. doi: 10.1038/s41598-022-07324-y.
Head and neck cancer is the sixth most common cancer in the world, with more than 300,000 deaths attributed to the disease annually. Aggressive surgical resection often with adjuvant chemoradiation is the cornerstone of treatment. However, the necessary chemoradiation treatment can result in collateral damage to adjacent vital structures causing a profound impact on quality of life. Here, we present a novel polymer of poly(lactic-co-glycolic) acid and polyvinyl alcohol that can serve as a versatile multidrug delivery platform as well as for detection on cross-sectional imaging while functioning as a fiduciary marker for postoperative radiotherapy and radiotherapeutic dosing. In a mouse xenograft model, the dual-layered polymer composed of calcium carbonate/thymoquinone was used for both polymer localization and narrow-field infusion of a natural therapeutic compound. A similar approach can be applied in the treatment of head and neck cancer patients, where immunotherapy and traditional chemotherapy can be delivered simultaneously with independent release kinetics.
头颈部癌症是世界上第六大常见癌症，每年有超过 30 万人死于该疾病。积极的手术切除，通常辅以辅助放化疗，是治疗的基石。然而，必要的放化疗会对相邻的重要结构造成附带损伤，从而对生活质量产生深远影响。在这里，我们提出了一种新型聚（丙交酯-共-乙交酯）和聚乙烯醇的聚合物，它可以作为一种多功能的多药物输送平台，用于横断面成像检测，同时作为术后放射治疗和放射治疗剂量的基准标记物。在小鼠异种移植模型中，由碳酸钙/百里醌组成的双层聚合物用于聚合物定位和天然治疗化合物的窄场输注。类似的方法可以应用于头颈部癌症患者的治疗中，其中免疫疗法和传统化疗可以同时以独立的释放动力学进行。
