Department of Biomedical and Molecular Sciences, Queen's University,
Postgraduate Medical Education, Graduate Diploma and Professional Master in Medical Sciences, School of Medicine, Queen's University.
Int J Nanomedicine. 2018 Aug 20;13:4727-4745. doi: 10.2147/IJN.S168053. eCollection 2018.
Advances in nanomedicine have become indispensable for targeted drug delivery, early detection, and increasingly personalized approaches to cancer treatment. Nanoparticle-based drug-delivery systems have overcome some of the limitations associated with traditional cancer-therapy administration, such as reduced drug solubility, chemoresistance, systemic toxicity, narrow therapeutic indices, and poor oral bioavailability. Advances in the field of nanomedicine include "smart" drug delivery, or multiple levels of targeting, and extended-release drug-delivery systems that provide additional methods of overcoming these limitations. More recently, the idea of combining smart drug delivery with extended-release has emerged in hopes of developing highly efficient nanoparticles with improved delivery, bioavailability, and safety profiles. Although functionalized and extended-release drug-delivery systems have been studied extensively, there remain gaps in the literature concerning their application in cancer treatment. We aim to provide an overview of smart and extended-release drug-delivery systems for the delivery of cancer therapies, as well as to introduce innovative advancements in nanoparticle design incorporating these principles. With the growing need for increasingly personalized medicine in cancer treatment, smart extended-release nanoparticles have the potential to enhance chemotherapy delivery, patient adherence, and treatment outcomes in cancer patients.
纳米医学的进步对于靶向药物输送、早期检测以及日益个性化的癌症治疗方法至关重要。基于纳米粒子的药物输送系统克服了传统癌症治疗管理中存在的一些限制，例如降低药物溶解度、化疗耐药性、全身毒性、狭窄的治疗指数和较差的口服生物利用度。纳米医学领域的进展包括“智能”药物输送或多层次靶向以及延长释放药物输送系统，这些系统提供了克服这些限制的额外方法。最近，将智能药物输送与延长释放相结合的想法已经出现，希望开发出具有改善的输送、生物利用度和安全性的高效纳米粒子。尽管已经对功能化和延长释放药物输送系统进行了广泛的研究，但在其在癌症治疗中的应用方面，文献中仍存在空白。我们旨在提供智能和延长释放药物输送系统在癌症治疗中的应用概述，并介绍结合这些原理的纳米粒子设计的创新进展。随着癌症治疗中对日益个性化医学的需求不断增长，智能延长释放纳米粒子有可能增强化疗药物的输送、患者的依从性以及癌症患者的治疗效果。
