5-HTT 基因型与普通人群青少年和年轻成年人负性情绪的惰性。
5-HTT genotype and inertia of negative affect in adolescents and young adults from the general population.
机构信息
Behavioral Epidemiology, Institute of Clinical Psychology and Psychotherapy, Technische Universität Dresden, Chemnitzer Str. 46, 01187, Dresden, Germany.
Center for Clinical Epidemiology and Longitudinal Studies (CELOS), Institute of Clinical Psychology and Psychotherapy, Technische Universität Dresden, Dresden, Germany.
出版信息
J Neural Transm (Vienna). 2022 Mar;129(3):343-351. doi: 10.1007/s00702-022-02459-8. Epub 2022 Mar 4.
The study aims to replicate the previous found association of 5-HTTLPR and inertia of negative affect in daily life of adolescents and young adults. Data of 877 adolescents (aged 14-21 years) of the Behavior and Mind Health (BeMIND) study (epidemiological cohort study, Dresden, Germany) were genotyped for 5-HTTLPR/rs25531, grouped into SS/SL/SL/LL/LL vs. LL, and provided ratings on negative affect items, depression and anxiety (Patient-Reported Outcomes Measurement Information System) eight times a day over 4 days. Multilevel regression models did not reveal an association of 5-HTTLPR genotype and inertia of negative affect, nor associations with inertia of anxiety or depression. Inertia of negative affect seems not to be a psychological mechanism through which 5-HTTLPR acts on psychopathology.
这项研究旨在复制先前发现的 5-HTTLPR 与青少年和年轻人日常生活中消极影响的惰性之间的关联。行为与心理健康（BeMIND）研究（德国德累斯顿的一项流行病学队列研究）的 877 名青少年（年龄 14-21 岁）的数据进行了 5-HTTLPR/rs25531 基因分型，分为 SS/SL/SL/LL/LL 与 LL，每天在 4 天内进行 8 次对负性情绪项目、抑郁和焦虑（患者报告的结果测量信息系统）进行评分。多层次回归模型并未显示 5-HTTLPR 基因型与消极影响的惰性之间存在关联，也未显示与焦虑或抑郁的惰性之间存在关联。消极影响的惰性似乎不是 5-HTTLPR 作用于精神病理学的心理机制。
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