Department of Psychiatry and Psychotherapy, University of Muenster, Muenster, Germany.
Depress Anxiety. 2011 Dec 21;28(12):1048-57. doi: 10.1002/da.20840. Epub 2011 Jun 16.
Genetic factors and environmental factors are assumed to interactively influence the pathogenesis of anxiety disorders. Thus, a gene-environment interaction (G × E) study was conducted with respect to anxiety sensitivity (AS) as a promising intermediate phenotype of anxiety disorders.
Healthy subjects (N = 363) were assessed for AS, childhood maltreatment (Childhood Trauma Questionnaire), and genotyped for functional serotonin transporter gene variants (5-HTTLPR/5-HTT rs25531). The influence of genetic and environmental variables on AS and its subdimensions was determined by a step-wise hierarchical regression and a multiple indicator multiple cause (MIMIC) model.
A significant G × E effect of the more active 5-HTT genotypes and childhood maltreatment on AS was observed. Furthermore, genotype (LL)-childhood trauma interaction particularly influenced somatic AS subdimensions, whereas cognitive subdimensions were affected by childhood maltreatment only.
Results indicate a G × E effect of the more active 5-HTT genotypes and childhood maltreatment on AS, with particular impact on its somatic subcomponent.
遗传因素和环境因素被认为会相互作用影响焦虑障碍的发病机制。因此，进行了一项关于焦虑敏感（AS）作为焦虑障碍有前途的中间表型的基因-环境相互作用（G×E）研究。
健康受试者（N=363）评估了 AS、儿童期虐待（儿童期创伤问卷）和功能性 5-羟色胺转运体基因变体（5-HTTLPR/5-HTT rs25531）的基因型。通过逐步分层回归和多指标多原因（MIMIC）模型确定遗传和环境变量对 AS 及其亚维度的影响。
观察到更活跃的 5-HTT 基因型和儿童期虐待对 AS 的显著 G×E 效应。此外，基因型（LL）-儿童期创伤的相互作用特别影响躯体 AS 亚维度，而认知亚维度仅受儿童期创伤的影响。
结果表明，更活跃的 5-HTT 基因型和儿童期虐待对 AS 存在 G×E 效应，对其躯体亚成分的影响尤其明显。
