Padovani E M, Fanos V, Dal Moro A, Chiaffoni G P, Fostini R, Girelli M, Boner A
Biol Res Pregnancy Perinatol. 1986;7(2):71-3.
Ceftazidime pharmacokinetics were studied in 13 preterm newborns requiring antibiotic treatment, following intramuscular administration of a 50 mg/kg dose in the first 24 hours of life. The main pharmacokinetic parameters (peak concentration, time to reach peak, plasma half-life, area under the curve, elimination constant, distribution volume and plasma clearance) were determined directly from the serum concentrations observed. The clinical and bacteriological response to ceftazidime treatment was good; no side effects or alterations of biohumoral parameters were noted.
对13名需要抗生素治疗的早产新生儿进行了头孢他啶的药代动力学研究，这些新生儿在出生后的头24小时内接受了50mg/kg剂量的肌肉注射。主要药代动力学参数（峰值浓度、达峰时间、血浆半衰期、曲线下面积、消除常数、分布容积和血浆清除率）直接根据观察到的血清浓度确定。头孢他啶治疗的临床和细菌学反应良好；未观察到副作用或生物体液参数的改变。
