Rule R, Martiarena N J, Rubio M, Magadan A
Facultad de Ciencias Médicas, Universidad Nacional de La Plata, Buenos Aires, Argentina.
Medicina (B Aires). 1993;53(3):207-10.
A pharmacokinetic study of ceftazidime was performed in newborn children. Six premature infants with a body weight up to 2000 g and with symptoms of pneumonia (Table 1) were treated with ceftazidime (50 mg/kg body weight) by endovenous route. Plasma concentrations of the antibiotic (Fig. 1) were determined by HPLC. A kinetic behavior was described through a compartment model independent analysis. The calculated parameters were as follows: half-life (T1/2z = 4.05 +/- 0.81 h) apparent volume of distribution (Vz = 686.0 +/- 258.6 ml/kg), elimination rate constant (lambda z = 0.18 +/- 0.04h-1), area under curve (AUC = 464.4 +/- 139.1 mu gh/ml, mean residence time (MRT = 5.2 +/- 1.3 h), and total clearance (CI = 114.9 +/- 30.0 ml/h. kg) (Table 2). Good correlation was observed (r = 0.83, p < 0.05 between lambda z = and Vz). The loading and maintenance doses calculated for enterobacteria and P. aeruginosa were 15 and 13 mg/kg i.v. respectively each 12 h.
对新生儿进行了头孢他啶的药代动力学研究。六名体重达2000克且有肺炎症状的早产儿（表1）通过静脉途径接受头孢他啶（50毫克/千克体重）治疗。抗生素的血浆浓度（图1）通过高效液相色谱法测定。通过房室模型独立分析描述了动力学行为。计算得到的参数如下：半衰期（T1/2z = 4.05 +/- 0.81小时）、表观分布容积（Vz = 686.0 +/- 258.6毫升/千克）、消除速率常数（lambda z = 0.18 +/- 0.04h-1）、曲线下面积（AUC = 464.4 +/- 139.1微克小时/毫升）、平均驻留时间（MRT = 5.2 +/- 1.3小时）和总清除率（CI = 114.9 +/- 30.0毫升/小时·千克）（表2）。观察到良好的相关性（r = 0.83，lambda z与Vz之间p < 0.05）。针对肠杆菌和铜绿假单胞菌计算的负荷剂量和维持剂量分别为每12小时静脉注射15毫克/千克和13毫克/千克。
