治疗性血液成分单采术用于溃疡性结肠炎诱导治疗及肠外皮肤表现的疗效
Efficacy of cytapheresis for induction therapy and extra-intestinal skin manifestations of ulcerative colitis.
作者信息
Shibuya Tomoyoshi, Nomura Osamu, Nomura Kei, Haraikawa Mayuko, Haga Keiichi, Ishikawa Dai, Osada Taro, Yamaji Ken, Ikeda Shigaku, Nagahara Akihito
机构信息
Department of Gastroenterology, Juntendo University School of Medicine, Tokyo, Japan.
Department of Gastroenterology, Juntendo University Urayasu Hospital, Urayasu, Japan.
出版信息
Ther Apher Dial. 2022 Jun;26(3):522-528. doi: 10.1111/1744-9987.13823. Epub 2022 Mar 10.
INTRODUCTION
In recent years, the prevalence of inflammatory bowel diseases has been increasing in Japan due to the westernization of lifestyles. Many patients have been reported to have extra-intestinal manifestations (EIMs) at least once. Skin lesions occur with a high degree of frequency among EIMs, with erythema nodosum (EN) and pyoderma gangrenosum (PG) the main complications. Cytapheresis is again attracting attention as a treatment with few side effects.
METHODS
We investigated the therapeutic effect of cytapheresis on ulcerative colitis (UC) and cutaneous EIMs. Between 2008 and 2021, 240 patients with active UC had induction therapy by cytapheresis at our hospital.
RESULTS
Remission and response rates were 50.0% and 67.5%, respectively. Apheresis was performed on seven patients with PG and five patients with EN with a good response. Serious adverse events were not observed.
CONCLUSION
This retrospective assessment of efficacy showed that EN and PG responded favorably to cytapheresis.
引言
近年来，由于生活方式的西化，日本炎症性肠病的患病率一直在上升。据报道，许多患者至少有一次肠外表现（EIMs）。皮肤病变在EIMs中出现的频率很高，主要并发症为结节性红斑（EN）和坏疽性脓皮病（PG）。细胞分离术作为一种副作用少的治疗方法再次受到关注。
方法
我们研究了细胞分离术对溃疡性结肠炎（UC）和皮肤EIMs的治疗效果。2008年至2021年期间，我院对240例活动期UC患者进行了细胞分离术诱导治疗。
结果
缓解率和有效率分别为50.0%和67.5%。对7例PG患者和5例EN患者进行了血液成分单采，反应良好。未观察到严重不良事件。
结论
这项疗效的回顾性评估表明，EN和PG对细胞分离术反应良好。
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