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分析股骨转子间骨折术后异体输血需求的危险因素。

Analysis of The Risk Factors for Postoperative Allogenic Blood Transfusion Requirement in Intertrochanteric Femur Fractures.

机构信息

Department of Orthopaedic and Traumatology, Bartın State Hospital, Bartın, Turkey.

Department of Orthopaedic and Traumatology, Tepecik Training and Research Hospital, İzmir; Turkey.

出版信息

Acta Chir Orthop Traumatol Cech. 2022;89(1):48-52.

Abstract

PURPOSE OF THE STUDY Hemoglobin (Hb) levels tend to decrease in patients after hip fractures. There are several factors that is responsible for this decrease in Hb levels. The primary aim in this study was to evaluate the risk factors of blood loss in patients with IFF and to determine the limits that may require allogeneic blood transfusion (ABT), and the secondary aim was to prevent unnecessary blood crossing outside these limits. MATERIAL AND METHODS 119 patients with intertrochanteric femur fracture (IFF) were included in the study. The patients were divided into two groups according to the use of ABT in the postoperative period. Age, gender, fracture side, height, weight, body mass index (BMI), American Society of Anesthesiologist (ASA) score, preoperative hemoglobin (Hb) level, platelet (Plt) number, International Normalized Ratio (INR), prothrombin time (PT), activated partial thromboplastin time (aPTT) values, comorbid diseases, history of drug use, whether ABT was applied in the preoperative period or not, and the postoperative 1st day Hb levels were evaluated from the medical records. A p value below than 0.05 was accepted as statistically significant. RESULTS Advanced age [odds ratio (OR) 1.069, 95% confidence interval (CI) 0.372-3.202], unstable fracture type [OR 0.258, 95% CI 0.496-6.632], and hemoglobin level <11 g / dL [OR 5.574, 95% GA 0.312-65.278 was found to be an independent predictive risk factor for allogeneic blood transfusion requirement in the postoperative period. DISCUSSION There are several factors that is responsible for decrease in Hb levels in patients after hip fractures. The most important and most likely cause of these is the fracture itself. Other reasons are stated as type of fracture, time elapsed until the surgical treatment, preferred implants for treatment, advanced age, mean preoperative Hb value and anticoagulant drug usage in literature. Although the preoperative blood loss due to trauma is inevitable, unnecessary aggressive and/or inadequate treatments can be avoided if patients with higher bleeding risk and complication rate can be detected. CONCLUSIONS Advanced age, unstable fracture pattern and low preoperative Hb values should be considered as risk factors for the postoperative ABT requirements for patients with IFF. Key words: intertrochanteric femur fracture, allogenic blood transfusion, blood loss hemoglobin level.

摘要

目的

血红蛋白(Hb)水平在髋部骨折后往往会下降。有几个因素导致 Hb 水平下降。本研究的主要目的是评估 IFF 患者出血的危险因素,并确定可能需要异体输血(ABT)的限度,次要目的是防止在这些限度之外不必要的交叉配血。

材料与方法

将 119 例股骨转子间骨折(IFF)患者纳入研究。根据术后是否使用 ABT,将患者分为两组。从病历中评估年龄、性别、骨折侧、身高、体重、体重指数(BMI)、美国麻醉师协会(ASA)评分、术前 Hb 水平、血小板(Plt)数、国际标准化比值(INR)、凝血酶原时间(PT)、活化部分凝血活酶时间(aPTT)值、合并症、药物使用史、是否在术前使用 ABT 以及术后第 1 天 Hb 水平。p 值<0.05 被认为具有统计学意义。

结果

高龄[比值比(OR)1.069,95%置信区间(CI)0.372-3.202]、不稳定骨折类型[OR 0.258,95%CI 0.496-6.632]和血红蛋白水平<11 g/dL[OR 5.574,95%GA 0.312-65.278]被发现是术后异体输血需求的独立预测危险因素。

讨论

有几个因素会导致髋部骨折后 Hb 水平下降。最重要和最可能的原因是骨折本身。其他原因在文献中被描述为骨折类型、直到手术治疗的时间间隔、首选的治疗植入物、年龄较大、术前平均 Hb 值和抗凝药物的使用。尽管创伤引起的术前失血是不可避免的,但如果能够检测到具有更高出血风险和并发症率的患者,可以避免不必要的激进和/或不充分的治疗。

结论

高龄、不稳定的骨折模式和低术前 Hb 值应被视为 IFF 患者术后 ABT 需求的危险因素。

关键词

股骨转子间骨折、同种异体输血、失血、血红蛋白水平。

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