Suppr超能文献

富血小板血浆浸渗微化软骨同种异体移植增强的髋关节镜下微骨折术显著改善功能结局。

Hip Arthroscopic Microfracture Augmented With Platelet-Rich Plasma-Infused Micronized Cartilage Allograft Significantly Improves Functional Outcomes.

机构信息

Department of Orthopaedic Surgery, Wake Forest School of Medicine, Winston-Salem, North Carolina, U.S.A.

Department of Orthopaedic Surgery, Wake Forest School of Medicine, Winston-Salem, North Carolina, U.S.A.

出版信息

Arthroscopy. 2022 Oct;38(10):2819-2826.e1. doi: 10.1016/j.arthro.2022.02.021. Epub 2022 Mar 3.

Abstract

PURPOSE

To evaluate functional outcomes and survivorship in patients at 1 year after undergoing arthroscopic microfracture augmented with hyaline allograft for symptomatic chondral defects of the hip.

METHODS

Consecutive patients with and without prior hip procedures presenting with Outerbridge grade IV chondral lesion of the acetabulum or femoral head were prospectively followed. Patients underwent hip microfracture augmented with hyaline allograft suspended in autologous platelet-rich plasma between October 2016 and April 2018. Extent of cartilage degeneration was quantified using the chondromalacia severity index (CMI). Patient functional scores, including Tegner, Hip Outcome Score-Activities of Daily Living (HOS-ADL), Sport-Specific Subscale (HOS-SSS), modified Harris Hip Score (mHHS), and Nonarthritic Hip Score (NAHS) were collected preoperatively and at minimum 1-year postoperatively. Minimal clinically important difference (MCID) was analyzed. Statistical significance was established at P < .05. Pearson's coefficient analysis was performed to identify preoperative variables correlated with clinical outcomes.

RESULTS

Fifty-seven patients (86.4%) had minimum 1-year follow-up and were included in the final analysis, with a mean age and body mass index (BMI) of 38.3 ± 9.1 years and 27.7 ± 4.9 kg/m, respectively. Comparison of baseline and postoperative score averages demonstrated significant improvements in Tegner scores (3.7 ± 2.9 vs 5.1 ± 2.6; P = .003), HOS-ADL (63.3 ± 16.4 vs 89.1 ± 14.5; P < .001), HOS-SSS (40.8 ± 20.4 vs 79.5 ± 21.6; P < .001), mHHS (61.5 ± 16.2 vs 87.0 ± 17.7; P < .001), and NAHS (56.6 ± 14.9 vs 78.7 ± 18.3; P < .001). The percentage of patients who achieved MCID for HOS-ADL, HOS-SSS, mHHS, and NAHS were 89.8%, 83.0%, 75.6%, and 81.6%, respectively. Overall, 91.8% of patients met the threshold for achieving MCID in at least one outcome score. Of the 57 patients, 5 (8.8%) failed clinically, with 1 (1.8%) undergoing revision surgery and 4 (6.9%) undergoing conversion to total hip arthroplasty. There was a direct correlation between preoperative alpha angle and postoperative HOS-ADL. Femoral chondral lesion size and CMI inversely correlated with postoperative HOS-ADL.

CONCLUSIONS

Treatment of hip chondral defects with microfracture and hyaline allograft augmentation demonstrated excellent survivorship and significantly improved patient report outcomes at 1 year.

LEVEL OF EVIDENCE

IV, retrospective case series.

摘要

目的

评估行关节镜下微骨折术联合透明质异体移植物治疗髋关节症状性软骨缺损患者术后 1 年的功能结果和存活率。

方法

前瞻性随访连续就诊的髋关节手术患者和无髋关节手术史的患者,他们均存在髋臼或股骨头的 Outerbridge 分级 IV 级软骨病变。患者在 2016 年 10 月至 2018 年 4 月期间接受了透明质异体移植物联合富含血小板的血浆的髋关节微骨折术治疗。使用软骨软化严重指数(CMI)量化软骨退变程度。收集患者术前和至少 1 年后的功能评分,包括 Tegner、髋关节结果评分-日常生活活动(HOS-ADL)、专项运动量表(HOS-SSS)、改良 Harris 髋关节评分(mHHS)和非关节炎髋关节评分(NAHS)。分析最小临床重要差异(MCID)。以 P <.05 为统计学显著性标准。采用 Pearson 系数分析确定与临床结果相关的术前变量。

结果

57 例(86.4%)患者获得至少 1 年的随访并纳入最终分析,平均年龄和体重指数(BMI)分别为 38.3 ± 9.1 岁和 27.7 ± 4.9 kg/m²。与基线相比,术后评分平均值的比较显示 Tegner 评分(3.7 ± 2.9 与 5.1 ± 2.6;P =.003)、HOS-ADL(63.3 ± 16.4 与 89.1 ± 14.5;P <.001)、HOS-SSS(40.8 ± 20.4 与 79.5 ± 21.6;P <.001)、mHHS(61.5 ± 16.2 与 87.0 ± 17.7;P <.001)和 NAHS(56.6 ± 14.9 与 78.7 ± 18.3;P <.001)均有显著改善。达到 HOS-ADL、HOS-SSS、mHHS 和 NAHS 的 MCID 的患者百分比分别为 89.8%、83.0%、75.6%和 81.6%。总体而言,91.8%的患者至少有一项结局评分达到 MCID。在 57 例患者中,5 例(8.8%)临床失败,其中 1 例(1.8%)接受翻修手术,4 例(6.9%)接受全髋关节置换术。术前 α 角与术后 HOS-ADL 之间存在直接相关性。股骨软骨病变大小和 CMI 与术后 HOS-ADL 呈负相关。

结论

关节镜下微骨折术联合透明质异体移植物治疗髋关节软骨缺损,1 年后患者具有良好的存活率和显著改善的患者报告结局。

证据等级

IV,回顾性病例系列。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验