Jiang Sheng, Fu Zaiyang, Li Peilun, Shen Yanfei, Su Qun, Cai Guolong, Ning Gangmin
Department of Biomedical Engineering, Zhejiang University, Hangzhou, China; Zhejiang Lab, Hangzhou, China.
Department of Biomedical Engineering, Zhejiang University, Hangzhou, China.
Respir Physiol Neurobiol. 2022 Jun;300:103883. doi: 10.1016/j.resp.2022.103883. Epub 2022 Mar 2.
Lung diseases such as acute respiratory distress syndrome affect the patient's lung compliance, which in turn affects the ability of gas exchange. Changes in alveolar diameter relate to local lung compliance. How alveolar diameter affects gas exchange, particularly oxygen concentrations in alveolar capillaries, is a topic of concern for researchers, and can be studied using mathematical models. The level of small-scale mathematical models of the pulmonary circulatory system was the alveolar capillaries, but existing models do not consider the gas-exchange function and fail to reflect the influence of alveolar diameter. Therefore, we proposed a pulmonary acinar capillary model with gas exchange function, and most importantly, introduced alveolar diameter into the model, to analyze the effect of alveolar diameter on the gas exchange function of the pulmonary acini. The model was tested by three respiratory function simulation experiments. According to the simulation results of changing diameter, we found that the alveolar diameter mainly affects the alveolar gas exchange function of lung acinar inlets and the middle section compared with the peripheral section.
诸如急性呼吸窘迫综合征等肺部疾病会影响患者的肺顺应性，进而影响气体交换能力。肺泡直径的变化与局部肺顺应性相关。肺泡直径如何影响气体交换，尤其是肺泡毛细血管中的氧气浓度，是研究人员关注的一个话题，可以使用数学模型进行研究。肺循环系统小规模数学模型的层面是肺泡毛细血管，但现有模型未考虑气体交换功能，未能反映肺泡直径的影响。因此，我们提出了一个具有气体交换功能的肺腺泡毛细血管模型，最重要的是，将肺泡直径引入模型，以分析肺泡直径对肺腺泡气体交换功能的影响。该模型通过三个呼吸功能模拟实验进行了测试。根据直径变化的模拟结果，我们发现与外周部分相比，肺泡直径主要影响肺腺泡入口和中间部分的肺泡气体交换功能。
