抗体介导性脑炎的最新进展：抗 LGI1 和抗 Caspr2 抗体（Ab）介导的脑炎。
Contemporary advances in antibody-mediated encephalitis: anti-LGI1 and anti-Caspr2 antibody (Ab)-mediated encephalitides.
机构信息
Department of Neuroscience, Central Clinical School, Faculty of Medicine, Nursing and Health Science, Monash University, Melbourne, Victoria, Australia; Department of Neurology, Alfred Hospital, Melbourne, Victoria, Australia.
Department of Neuroscience, Central Clinical School, Faculty of Medicine, Nursing and Health Science, Monash University, Melbourne, Victoria, Australia; Department of Neurology, Alfred Hospital, Melbourne, Victoria, Australia; Department of Neurology, Royal Melbourne Hospital, Melbourne, Victoria, Australia.
出版信息
Autoimmun Rev. 2022 May;21(5):103074. doi: 10.1016/j.autrev.2022.103074. Epub 2022 Mar 3.
Encephalitides with antibodies directed against leucine-rich glioma-inactivated 1 (LGI1) and contactin-associated protein-like 2 (Caspr2) represent two increasingly well characterised forms of autoimmune encephalitis. Both share overlapping and distinct clinical features, are mediated by autoantibodies directed against differing proteins complexed with voltage-gated potassium channels, with unique genetic predisposition identified to date. Herein we summarise disease mechanisms, clinical features, treatment considerations, prognostic factors and clinical outcomes regarding these disorders.
具有针对富含亮氨酸胶质瘤失活 1 蛋白 (LGI1) 和接触蛋白相关蛋白 2 (Caspr2) 抗体的脑炎是两种越来越被明确的自身免疫性脑炎形式。这两种疾病具有重叠和独特的临床特征，都是由针对与电压门控钾通道结合的不同蛋白的自身抗体介导的，迄今为止已确定了独特的遗传易感性。本文总结了这些疾病的发病机制、临床特征、治疗注意事项、预后因素和临床转归。
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