El-Bayoumy Karam, Stoner Gary
Department of Biochemistry & Molecular Biology, College of Medicine, Pennsylvania State University, Hershey, Pennsylvania.
Department of Medicine, College of Medicine, Ohio State University, Columbus, Ohio.
Cancer Prev Res (Phila). 2022 Mar 1;15(3):139-141. doi: 10.1158/1940-6207.CAPR-21-0633.
Bonorden and colleagues designed a clinical trial to test the hypothesis that daily consumption of freeze-dried watercress, a rich source of the chemopreventive agent phenethyl isothiocyanate, can enhance the detoxification of well-known tobacco and environmental carcinogens and toxicants. Initial results have validated subject compliance and a positive outcome of this study would further support the use of watercress as a whole food-based approach to cancer chemoprevention. On the basis of the design of the clinical trial and the various biological samples to be collected, we discuss potential opportunities to test future hypotheses. See related article, p. 143.
博诺登及其同事设计了一项临床试验，以验证以下假设：每日食用冻干水芹（一种富含化学预防剂异硫氰酸苯乙酯的食物）能够增强对烟草及环境中常见致癌物和毒物的解毒作用。初步结果已证实受试者的依从性，而本研究若取得积极成果，将进一步支持把水芹作为一种基于全食物的癌症化学预防方法。基于该临床试验的设计以及计划收集的各类生物样本，我们讨论了未来检验相关假设的潜在机会。见相关文章，第143页。
