Peking University School of Nursing, No.38 Xueyuan Road, Haidian District, Beijing, China.
Zhejiang Chinese Medical University School of Nursing, No.548 Binwen Road, Binjiang District, Hangzhou, China.
BMC Musculoskelet Disord. 2022 Mar 5;23(1):213. doi: 10.1186/s12891-022-05137-8.
Both knee osteoarthritis (KOA) and depressive symptoms (DS) are major public health issues affecting the quality of life. This study aimed to examine the association between KOA and DS.
Data were gathered from the China Health and Retirement Longitudinal Study in 2011-2015 which surveyed middle-aged to elderly individuals and their spouses in 28 provinces in China. An adjusted Cox proportional hazards regression model was used to estimate hazard ratios (HRs).
The analysis for baseline KOA and the subsequent risk of DS was based on 2582 participants without baseline DS. During the follow-up, KOA patients were more likely to have DS than non-KOA participants (adjusted HR = 1.38: 95% CI = 1.23 to 1.83). The analysis for baseline DS and the subsequent risk of KOA was based on 4293 participants without baseline KOA, those with DS were more likely to develop KOA than non-DS participants (adjusted HR = 1.51: 95% CI = 1.26 to 1.81). Subgroup analysis showed sex and age had no significant moderating effect on the KOA-DS association.
Our results provide evidence that the association between KOA and DS is bidirectional. Therefore, primary prevention and management of KOA and DS should consider this relationship.
膝骨关节炎（KOA）和抑郁症状（DS）都是影响生活质量的重大公共卫生问题。本研究旨在探讨 KOA 和 DS 之间的关系。
数据来自 2011-2015 年中国健康与退休纵向研究，该研究调查了中国 28 个省份的中年至老年人及其配偶。采用校正的 Cox 比例风险回归模型来估计风险比（HR）。
对基线 KOA 和随后发生 DS 的风险分析基于 2582 名基线无 DS 的参与者。在随访期间，KOA 患者发生 DS 的可能性高于非 KOA 参与者（校正 HR=1.38：95%CI=1.23 至 1.83）。对基线 DS 和随后发生 KOA 的风险分析基于 4293 名基线无 KOA 的参与者，DS 患者发生 KOA 的可能性高于非 DS 参与者（校正 HR=1.51：95%CI=1.26 至 1.81）。亚组分析表明，性别和年龄对 KOA-DS 关联没有显著的调节作用。
我们的研究结果提供了证据，表明 KOA 和 DS 之间的关系是双向的。因此，KOA 和 DS 的一级预防和管理应考虑到这种关系。
