Hand and Foot Surgery Department, Shenzhen Second People's Hospital (The First Hospital Affiliated to Shenzhen University), Shenzhen 518000, China; Shenzhen Key Laboratory of Tissue Engineering, Shenzhen Laboratory of Digital Orthopedic Engineering, Guangdong Provincial Research Center for Artificial Intelligence and Digital Orthopedic Technology, Shenzhen Second People's Hospital (The First Hospital Affiliated to Shenzhen University, Health Science Center), Shenzhen 518035, China.
Hand and Foot Surgery Department, Shenzhen Second People's Hospital (The First Hospital Affiliated to Shenzhen University), Shenzhen 518000, China.
Biomed Pharmacother. 2022 Apr;148:112782. doi: 10.1016/j.biopha.2022.112782. Epub 2022 Mar 3.
Recently, cartilage tissue engineering has become a cornerstone to treat cartilage degeneration and osteoarthritis (OA). Fibronectin1 (FN1) is described as multiple functional glycoproteins that play an essential role in chondrogenic and osteogenic differentiation. Few studies reported the potential of FN1 to enhance tissue engineering and reduce the death of chondrocytes in OA. Further, FN1 possesses multiple binding domains including collagen, integrin, and heparin that can interact with heparan sulfate proteoglycans at the surface of chondrocyte leading to promote cell signaling and differentiation. Recent studies suggested that FN1 can promote chondrocyte differentiation by upregulating TGF-β/PI3K/Akt pathways. Further, FN1 can inhibit the apoptosis of chondrocytes by preventing the release of metalloproteinases through lowering the expression of p-PI3K/PI3K and p-AKT/AKT pathways. However, the use of FN1 in cartilage repair studies using animal models or clinical trials was rarely reported. Therefore, this article provides new insights into the importance of FN1 in cartilage tissue engineering to encourage more studies concerning FN1 in cartilage repair studies. Further, we provided new suggestions for advanced applications of FN1 to treat OA and cartilage degeneration.
最近，软骨组织工程已成为治疗软骨退变和骨关节炎（OA）的基石。纤连蛋白 1（FN1）被描述为具有多种功能的糖蛋白，在软骨形成和成骨分化中发挥着重要作用。很少有研究报道 FN1 具有增强组织工程和减少 OA 中软骨细胞死亡的潜力。此外，FN1 具有多个结合域，包括胶原蛋白、整合素和肝素，可与软骨细胞表面的硫酸乙酰肝素蛋白聚糖相互作用，从而促进细胞信号转导和分化。最近的研究表明，FN1 可以通过上调 TGF-β/PI3K/Akt 通路促进软骨细胞分化。此外，FN1 可以通过降低 p-PI3K/PI3K 和 p-AKT/AKT 通路的表达来抑制软骨细胞的凋亡，从而阻止金属蛋白酶的释放。然而，FN1 在动物模型或临床试验中的软骨修复研究中很少被报道。因此，本文提供了 FN1 在软骨组织工程中的重要性的新见解，以鼓励更多关于 FN1 在软骨修复研究中的研究。此外，我们为 FN1 治疗 OA 和软骨退变的高级应用提供了新的建议。
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