Childrens Hospital Aarau, Division of Pediatric Neurology, Switzerland; University Childrens Hospital Basel, Division of Pediatric Neurology and Developmental Medicine, Switzerland.
University Childrens Hospital Basel, Division of Pediatric Neurology and Developmental Medicine, Switzerland.
Eur J Paediatr Neurol. 2022 May;38:1-6. doi: 10.1016/j.ejpn.2022.01.021. Epub 2022 Feb 26.
Socioeconomic factors play a role in the outcome of chronic diseases in childhood. Epilepsy is the most common chronic neurological disease in childhood. The relationship between socioeconomic factors and prevalence, adherence and outcome in children with epilepsy has not been systematically reviewed and therefore the aim of our study.
Searches were conducted in PubMed, Embase and Cochrane databases from the first documented publications until 31st May 2020. The keywords included socioeconomic status, epilepsy, anticonvulsant, children and systematic review.
The search generated 4687 abstracts. 26 articles were included in the final analysis after the screening process. We found one paper regarding prevalence, 12 regarding adherence and 13 regarding outcome and their relationship to socioeconomic factors. Socioeconomic factors of caregivers impacted school performance, seizure freedom, quality of life and risk of unemployment in adulthood. Lower socioeconomic status was associated with non-adherence. Epilepsy may be more prevalent in children living in lower socioeconomic neighborhoods.
Socioeconomic factors of the caregiver, especially their level of education, annual income and marital status, had a significant impact on the outcome and adherence to anticonvulsants in children with epilepsy. Children belonging to a lower socioeconomic group are at risk of having poorer outcomes regarding adherence and hence remission, quality of life and academic achievement. We need to recognize this important aspect and take it into account when making a treatment plan for children with epilepsy.
社会经济因素在儿童慢性病的结局中起作用。癫痫是儿童最常见的慢性神经系统疾病。社会经济因素与儿童癫痫的患病率、治疗依从性和结局之间的关系尚未被系统地评价，因此是本研究的目的。
从最早发表的文献开始，在 PubMed、Embase 和 Cochrane 数据库中进行了检索，检索时间截止到 2020 年 5 月 31 日。检索关键词包括社会经济地位、癫痫、抗癫痫药、儿童和系统评价。
检索生成了 4687 篇摘要。经过筛选，最终有 26 篇文章纳入了分析。我们发现了一篇关于患病率的文章，12 篇关于治疗依从性的文章，13 篇关于结局及其与社会经济因素关系的文章。照顾者的社会经济因素影响儿童的学习成绩、无癫痫发作、生活质量和成年后失业风险。社会经济地位较低与治疗依从性差有关。社会经济地位较低的儿童癫痫患病率可能更高。
照顾者的社会经济因素，特别是他们的教育水平、年收入和婚姻状况，对儿童癫痫患者的结局和抗癫痫药物治疗依从性有显著影响。属于较低社会经济群体的儿童在治疗依从性方面存在较差结局的风险，从而影响缓解率、生活质量和学业成绩。我们需要认识到这一重要方面，并在为癫痫儿童制定治疗计划时加以考虑。
