Centre for Cancer Cell Reprogramming, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Montebello, N-0379 Oslo, Norway; Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital, Montebello, N-0379 Oslo, Norway.
Centre for Cancer Cell Reprogramming, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Montebello, N-0379 Oslo, Norway; Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital, Montebello, N-0379 Oslo, Norway.
Curr Opin Cell Biol. 2022 Apr;75:102062. doi: 10.1016/j.ceb.2022.01.007. Epub 2022 Mar 3.
The endosomal sorting complex required for transport (ESCRT) machinery evolved early in evolution to sculpt and cut cellular membranes. Consisting of three subcomplexes termed ESCRT-I, -II and -III, this machinery is recruited to various cellular locations to perform key steps in essential processes such as protein degradation, cell division, and membrane sealing. Here we review recent discoveries that have shed light on biophysical and molecular mechanisms of ESCRTs in endolysosomal protein degradation and nuclear envelope sealing, and we discuss how dysfunctional ESCRTs can lead to diseases such as cancer and neurodegenerative disorders.
内体分选复合物需要运输 (ESCRT) 机械进化早期塑造和切割细胞膜。由三个亚基复合物称为 ESCRT-I、-II 和 -III，该机械被招募到各种细胞位置执行关键步骤在重要过程中，如蛋白质降解、细胞分裂和膜密封。在这里，我们回顾了最近的发现，这些发现揭示了 ESCRTs 在溶酶体蛋白降解和核膜密封中的生物物理和分子机制，并讨论了功能失调的 ESCRTs 如何导致癌症和神经退行性疾病等疾病。
