Meier R F, Sieber R, Bauerfeind P, Blum A L
Clin Gastroenterol. 1986 Apr;15(2):377-91.
Endoscopy should not be the sole final arbiter in controlled clinical trials of peptic disorders. Data on the response of symptoms to treatment and the occurrence of side-effects may be not as 'hard' as endoscopically assessed 'healing' and 'relapse', but may be clinically more meaningful. Furthermore, in most recent trials, 'healing' and 'relapse' were poorly defined; important information on residual mucosal lesions after healing was often neglected.
在内镜检查不应成为消化性疾病对照临床试验中的唯一最终判定标准。症状对治疗的反应以及副作用发生情况的数据，可能不像内镜评估的“愈合”和“复发”那样“确凿”，但在临床上可能更具意义。此外，在最近的大多数试验中，“愈合”和“复发”的定义不明确；愈合后残留黏膜病变的重要信息常常被忽视。
