Pace F, Sangaletti O, Bianchi Porro G
Gastrointestinal Unit, L. Sacco Hospital, Milan, Italy.
Gut. 1990 Sep;31(9):1025-9. doi: 10.1136/gut.31.9.1025.
In order to investigate the response of gastro-oesophageal reflux after medically induced healing of oesophagitis and its relation to the occurrence of relapse during prophylactic treatment, 20 patients with erosive/ulcerative oesophagitis underwent 24 hour oesophageal pH monitoring before and after healing achieved with 12 to 24 week treatment with ranitidine 150 or 300 mg twice daily. Compared with pretreatment values, after macroscopic healing, a significant reduction in daytime median percentage of reflux time (10.0 v 6.5; p less than 0.05) and median number of reflux episodes lasting more than 5 minutes (5-5 v 1.0; p less than 0.05) were observed, whereas during night time reflux frequency and severity did not change. During maintenance treatment with ranitidine 150 or 300 mg nocte, five of the six patients, who had shown no improvement in gastro-oesophageal reflux after acute healing, relapsed. These results suggest that, in contrast with previous work, a decrease in gastro-oesophageal reflux in patients with reflux oesophagitis can be achieved after macroscopic healing, and that the occurrence of such a reduction after acute healing is predictive of a good response to longterm treatment.
为了研究食管炎药物治愈后胃食管反流的反应及其与预防性治疗期间复发的关系，20例糜烂性/溃疡性食管炎患者在使用雷尼替丁150或300毫克每日两次进行12至24周治疗达到愈合前后，接受了24小时食管pH监测。与治疗前的值相比，在宏观愈合后，观察到白天反流时间中位数百分比显著降低（10.0对6.5；p<0.05）以及持续超过5分钟的反流发作中位数显著降低（5.5对1.0；p<0.05），而夜间反流频率和严重程度没有变化。在使用雷尼替丁150或300毫克每晚维持治疗期间，6例急性愈合后胃食管反流无改善的患者中有5例复发。这些结果表明，与之前的研究不同，反流性食管炎患者在宏观愈合后胃食管反流可以降低，并且急性愈合后出现这种降低预示着对长期治疗有良好反应。
