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关于专家 HIV 绝经服务的思考:HIV 感染者女性管理绝经的经验:HIV 感染者女性管理绝经的经验。

Reflections on a specialist HIV menopause service: Experiences of managing menopause in women living with HIV: Experiences of managing menopause in women living with HIV.

机构信息

Chelsea and Westminster Hospital NHS Foundation Trust, London, UK.

出版信息

HIV Med. 2022 Apr;23(4):426-433. doi: 10.1111/hiv.13256.

Abstract

OBJECTIVES

We describe here characteristics and clinical outcomes of women living with HIV attending an HIV menopause service.

METHODS

This was a retrospective case note review of women attending the monthly HIV menopause clinic from January 2015 to July 2018.

RESULTS

In all, 55 women attended the service. The overall mean age was 49 years; 50% were black and 20% had a previous AIDS-defining condition. All were on antiretroviral therapy (ART); the median CD4 count was 678 cells/µL; 93% had a viral load < 50 copies/mL; 7% had previous hepatitis C infection; 27% had a history of smoking; 45% had risk factors or existing cardiovascular disease; 24% had a mental health condition. The median duration of symptoms before clinic attendance was 18 months. Vasomotor symptoms (84%), menstrual cycle changes (62%), psychological (56%) and urogenital symptoms (29%) were reported. Twenty-two per cent had early menopause or premature ovarian insufficiency. The mean age at attendance of women diagnosed with menopause (n = 24) was 52 years. However, their average duration of symptoms prior to review was 28 months. A total of 61% had osteopenia/osteoporosis, 73% received menopausal hormone therapy (MHT), and 73% had symptomatic improvement, although 58% of these required higher doses of MHT. Median time on MHT was 10 months. Five patients had their ART modified. No serious MHT adverse effects were observed.

CONCLUSIONS

Menopausal hormone therapy uptake was high, with most women observing an improvement in symptoms. Comorbidities were common, highlighting the need for integrated care based on a woman's needs. The long delay from initial symptoms to treatment demonstrates the need for better access to specialist advice for women experiencing menopause.

摘要

目的

我们在此描述了接受 HIV 绝经期服务的 HIV 感染者女性的特征和临床结局。

方法

这是一项回顾性病历审查,对 2015 年 1 月至 2018 年 7 月期间每月参加 HIV 绝经期门诊的女性进行了评估。

结果

共有 55 名女性参加了该服务。总体平均年龄为 49 岁;50%为黑人,20%有过艾滋病定义性疾病。所有患者均接受抗逆转录病毒治疗(ART);中位 CD4 计数为 678 个/μL;93%的病毒载量<50 拷贝/ml;7%有丙型肝炎既往感染史;27%有吸烟史;45%有心血管疾病的危险因素或已确诊的心血管疾病;24%有心理健康状况。就诊前症状持续时间的中位数为 18 个月。血管舒缩症状(84%)、月经周期改变(62%)、心理(56%)和泌尿生殖系统症状(29%)均有报道。22%有早绝经或卵巢早衰。确诊为绝经(n=24)的女性就诊时的平均年龄为 52 岁。然而,她们在接受评估前的平均症状持续时间为 28 个月。共有 61%有骨量减少/骨质疏松症,73%接受了绝经激素治疗(MHT),73%症状得到改善,尽管其中 58%需要更高剂量的 MHT。MHT 的中位时间为 10 个月。5 名患者的 ART 进行了调整。未观察到严重的 MHT 不良反应。

结论

MHT 的使用率很高,大多数女性的症状都有所改善。合并症很常见,这突出表明需要根据女性的需求提供综合护理。从最初症状到治疗的漫长延迟表明,需要更好地为经历绝经期的女性提供获得专家建议的机会。

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