Institute for Global Health, University College London, UK.
Royal Free London NHS Foundation Trust, UK.
AIDS Care. 2021 Jan;33(1):101-108. doi: 10.1080/09540121.2020.1748559. Epub 2020 Apr 11.
Using data from the PRIME Study, an observational study of the menopause in women living with HIV in England, we explored the association between menopausal symptoms and: (i) antiretroviral therapy (ART) adherence and (ii) HIV clinic attendance. We measured menopausal symptom severity with the Menopause Rating Scale (MRS, score ≥17 indicating severe symptoms), adherence with the CPCRA Antiretroviral Medication Adherence Self-Report Form, and ascertained HIV clinic attendance via self-report. Odds ratios were obtained using logistic regression. Women who reported severe menopausal symptoms had greater odds of suboptimal ART adherence (adjusted odds ratio (AOR) 2.22; 95% CI 1.13, 4.35) and suboptimal clinic attendance (AOR 1.52; 95% CI 1.01, 2.29). When psychological, somatic and urogenital domains of the MRS were analysed individually there was no association between adherence and severe symptoms (all > 0.1), however there was an association between suboptimal HIV clinic attendance and severe somatic (AOR 1.98; 95% CI 1.24, 3.16) and psychological (AOR 1.76; 95% CI 1.17, 2.65) symptoms. Severe menopausal symptoms were significantly associated with sub-optimal ART adherence and HIV clinic attendance, however we cannot infer causality, highlighting the need for longitudinal data.
利用英国艾滋病毒感染者绝经观察性研究（PRIME 研究）的数据，我们探讨了绝经症状与：（i）抗逆转录病毒治疗（ART）依从性和（ii）艾滋病毒门诊就诊之间的关联。我们使用绝经评定量表（MRS，得分≥17 表明有严重症状）来衡量绝经症状的严重程度，使用 CPCRA 抗逆转录病毒药物依从性自我报告表来衡量依从性，并通过自我报告来确定艾滋病毒门诊就诊情况。使用逻辑回归获得比值比。报告有严重绝经症状的女性 ART 依从性不佳的可能性更高（调整后的比值比（AOR）2.22；95%CI 1.13，4.35），且去艾滋病毒门诊就诊的情况不佳的可能性更高（AOR 1.52；95%CI 1.01，2.29）。当单独分析 MRS 的心理、躯体和泌尿生殖领域时，在依从性与严重症状之间没有关联（均>0.1），但是在 HIV 门诊就诊不佳与严重躯体症状（AOR 1.98；95%CI 1.24，3.16）和心理症状（AOR 1.76；95%CI 1.17，2.65）之间存在关联。严重的绝经症状与 ART 依从性不佳和 HIV 门诊就诊不佳显著相关，但我们不能推断因果关系，这凸显了对纵向数据的需求。
