补充丙酮酸钠对男性大学生足球运动员重复冲刺运动表现和恢复的影响：一项随机对照试验。
Effects of sodium pyruvate supplementation on repeated sprint exercise performance and recovery in male college soccer players: a randomized controlled trial.
机构信息
Department of Exercise Biochemistry, Exercise Science School, Beijing Sport University, Beijing, China.
Division of Pharmaceutical Research and Development, Shanghai Sandai Pharmaceutical R&D Co. Ltd., Shanghai, China.
出版信息
Ann Palliat Med. 2022 Feb;11(2):598-610. doi: 10.21037/apm-21-3862.
BACKGROUND
Sodium pyruvate (PYR) has been reported to improve aerobic metabolism and attenuate metabolic acidosis. Aerobic capacity and the ability to remove hydrogen ions affect the recovery from repeated high intensity activities. However, the effects of PYR supplementation on repeated sprint exercise (RSE) performance have not been elucidated. This study explored the effects of PYR ingestion on RSE ability and recovery.
METHODS
A total of 14 male soccer athletes (aged 20±2 years) participated in this double-blinded crossover study. The subjects completed two experimental sessions after randomized ingestion of either PYR or the maltodextrin placebo (PLA) for 1 week. At each session, participants completed high-intensity interval exercise (HIIE) and RSE 60 minutes after supplementation. Additionally, acid-base parameters in venous blood, energy system contributions, and power output were assessed.
RESULTS
Compared to PLA, PYR supplementation significantly increased the relative peak power output (PPO) of the first (P=0.034) and fifth (P=0.043) sprints, and the relative mean power output (MPO) of the fifth sprint (P=0.026). In addition, the mean PPO (P=0.031) and MPO (P=0.033) of sprints 1-6 were significantly elevated after PYR supplementation. After PYR administration, the phosphagen energy system [adenosine triphosphate (ATP)-phosphocreatine (PCr)] resynthesis of the fourth (P=0.034) and the overall recovery periods during HIIE (P=0.029) were higher than PLA administration. Additionally, the ATP-PCr resynthesis of the first (P=0.033) and fifth (P=0.019) recovery periods, and the mean of the six recovery periods during RSE (P=0.041) were increased in the PYR group compared to the PLA group. Furthermore, participants on the PYR regimen had higher blood pH, HCO3-, and base excess at pre-HIIE, post-HIIE, and pre-RSE (all P<0.05) compared to participants receiving PLA.
CONCLUSIONS
PYR supplementation enhanced RSE performance, and the improvement may be attributed to accelerated restoration of the acid-base balance and ATP-PCr regeneration.
TRIAL REGISTRATION
Chinese Clinical Trial Registry ChiCTR2100053936.
背景
丙酮酸（PYR）已被报道可改善有氧代谢并减轻代谢性酸中毒。有氧能力和清除氢离子的能力会影响反复高强度活动后的恢复。然而，PYR 补充对重复冲刺运动（RSE）表现的影响尚未阐明。本研究探讨了 PYR 摄入对 RSE 能力和恢复的影响。
方法
共有 14 名男性足球运动员（年龄 20±2 岁）参加了这项双盲交叉研究。在随机摄入 PYR 或麦芽糊精安慰剂（PLA）1 周后，受试者完成了两次实验。在每次实验中，参与者在补充后 60 分钟内完成高强度间歇运动（HIIE）和 RSE。此外，评估了静脉血中的酸碱参数、能量系统贡献和功率输出。
结果
与 PLA 相比，PYR 补充剂可显著增加第一（P=0.034）和第五（P=0.043）冲刺的相对峰值功率输出（PPO），以及第五冲刺的相对平均功率输出（MPO）（P=0.026）。此外，PYR 补充后，第一（P=0.031）和第五（P=0.033）冲刺的平均 PPO 和 MPO 均显著升高。PYR 给药后，HIIE 期间第四（P=0.034）和整体恢复期的磷酸原能量系统（三磷酸腺苷（ATP）-磷酸肌酸（PCr））再合成高于 PLA 给药（P=0.029）。此外，与 PLA 组相比，PYR 组在第一（P=0.033）和第五（P=0.019）恢复期以及 RSE 期间六个恢复期的平均 ATP-PCr 再合成（P=0.041）均增加。此外，与接受 PLA 的参与者相比，接受 PYR 方案的参与者在 HIIE 前、HIIE 后和 RSE 前的血液 pH 值、HCO3-和碱剩余更高（均 P<0.05）。
结论
PYR 补充剂增强了 RSE 表现，改善可能归因于酸碱平衡和 ATP-PCr 再生的加速恢复。
试验注册
中国临床试验注册中心 ChiCTR2100053936。
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