Olek Robert A, Kujach Sylwester, Radak Zsolt
Department of Athletics, Strength, and Conditioning, Poznan University of Physical Education, Poznan, Poland.
Department of Neurophysiology, Neuropsychology and Neuroinformatics, Medical University of Gdansk, Gdansk, Poland.
Sports Med Health Sci. 2024 Feb 28;6(4):295-301. doi: 10.1016/j.smhs.2024.02.007. eCollection 2024 Dec.
Pyruvate is a three-carbon ketoacid that occurs naturally in cells. It is produced through enzymatic reactions in the glycolytic pathway and plays a crucial role in energy metabolism. Despite promising early results, later well-controlled studies of physically active people have shown that pyruvate supplementation lasting more than 1 week has no ergogenic effects. However, some data suggest that ingested pyruvate may be preferentially metabolized without accumulation in the bloodstream. Pyruvate exhibits antioxidant activity and can affect the cellular redox state, and exogenous pyruvate can influence metabolism by affecting the acid-base balance of the blood. This brief review focuses on the potential effects of pyruvate as a supplement for active people. The current state of understanding suggests that studies of the effects of pyruvate supplementation should prioritize investigating the timing of pyruvate intake.
丙酮酸是一种三碳酮酸，在细胞中天然存在。它通过糖酵解途径中的酶促反应产生，在能量代谢中起着关键作用。尽管早期结果令人鼓舞，但后来对体育活动人群进行的严格对照研究表明，持续超过1周的丙酮酸补充并没有提高运动能力的效果。然而，一些数据表明，摄入的丙酮酸可能会被优先代谢，而不会在血液中积累。丙酮酸具有抗氧化活性，可影响细胞氧化还原状态，外源性丙酮酸可通过影响血液酸碱平衡来影响代谢。这篇简短的综述重点关注丙酮酸作为活跃人群补充剂的潜在影响。目前的认识状态表明，关于丙酮酸补充剂效果的研究应优先调查丙酮酸摄入的时间。
