Department of Laboratory Medicine, Jingzhou Hospital, Yangtze University, Jingzhou, China.
Department of Emergency, The Traditional Chinese Medicine Hospital of Wenjiang District, Chengdu, China.
Clin Appl Thromb Hemost. 2022 Jan-Dec;28:10760296221083681. doi: 10.1177/10760296221083681.
To retrospectively analyze the hematologic parameters in patients with early Diabetic Kidney Disease (DKD) to define potential biomarkers that can be used to predict early DKD.
134 diabetic patients without nephropathy and 49 patients with early DKD were enrolled for this study and the hematologic parameters were retrospectively analyzed. Paired comparison was conducted by T-test and the predicting value of any statistically different parameter was tested using the Receiver Operating Characteristic curve (ROC) analysis model.
The number of Neutrophil (N) was higher ( <0.001) while monocyte (M) was lower ( <0.01) in the early DKD group than that of DM group without nephropathy. In addition, neutrophil to lymphocyte ratio (NLR) was higher while platelet to lymphocyte ratio (PLR) was significantly lower in the early DKD group( <0.001). Results from ROC curve analysis showed the sensitivity and specificity of PLR to predict early DKD were 83.7% and 82.6%, respectively.
PLR may be a potential hematologic parameter that can be used to predict early DKD.
回顾性分析早期糖尿病肾病（DKD）患者的血液学参数，以确定可用于预测早期 DKD 的潜在生物标志物。
本研究纳入了 134 例无肾病的糖尿病患者和 49 例早期 DKD 患者，并对血液学参数进行了回顾性分析。采用 T 检验进行配对比较，使用受试者工作特征曲线（ROC）分析模型对任何具有统计学差异的参数的预测价值进行测试。
早期 DKD 组的中性粒细胞（N）数量高于 DM 组（<0.001），而单核细胞（M）数量低于 DM 组（<0.01）。此外，早期 DKD 组的中性粒细胞与淋巴细胞比值（NLR）较高，血小板与淋巴细胞比值（PLR）显著较低（<0.001）。ROC 曲线分析结果显示，PLR 预测早期 DKD 的灵敏度和特异性分别为 83.7%和 82.6%。
PLR 可能是一种可用于预测早期 DKD 的潜在血液学参数。
