Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Department of Endocrinology, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
Diabetes Res Clin Pract. 2021 Feb;172:108645. doi: 10.1016/j.diabres.2020.108645. Epub 2020 Dec 24.
The microbiome is greatly significant for immune system development and homeostasis. Dysbiosis in gut microbial composition and function is linked to immune responses and the development of metabolic diseases, including diabetes mellitus (DM). However, skin microbiome changes in diabetic patients and their role in DM are poorly elucidated. In this review, we summarize recent findings about the association between the gut and skin microbiota and DM, highlighting their roles in the proinflammatory status of DM. Moreover, although there is evidence that the connection between the gut and skin causes the same activated innate immune response, additional studies are needed to explore the mechanism. These findings might inform future DM prevention, diagnosis and treatment.
微生物组对于免疫系统的发育和稳态具有重要意义。肠道微生物组成和功能的失调与免疫反应和代谢疾病（包括糖尿病）的发展有关。然而，糖尿病患者的皮肤微生物组变化及其在糖尿病中的作用仍不清楚。在这篇综述中，我们总结了肠道和皮肤微生物组与糖尿病之间的关联的最新发现，强调了它们在糖尿病促炎状态中的作用。此外，尽管有证据表明肠道和皮肤之间的联系会引起相同的固有免疫激活反应，但仍需要更多的研究来探索其机制。这些发现可能为未来的糖尿病预防、诊断和治疗提供信息。
