Wellcome Centre for Ethics and Humanities and Ethox Centre, Nuffield Department of Population Health, University of Oxford, Big Data Institute, Oxford, OX3 7LF, USA.
Eur J Hum Genet. 2022 Aug;30(8):875-879. doi: 10.1038/s41431-022-01058-1. Epub 2022 Mar 7.
There is evidence to suggest that host genomic factors may account for disease response variability in COVID-19 infection. In this paper, we consider if and how host genomics should influence decisions about vaccine allocation. Three potential host genetic factors are explored: vulnerability to infection, resistance to infection, and increased infectivity. We argue for the prioritisation of the genetically vulnerable in vaccination schemes, and evaluate the potential for ethical de-prioritisation of individuals with genetic markers for resistance. Lastly, we discuss ethical prioritisation of individuals with genetic markers for increased infectivity (those more likely to spread COVID-19).
有证据表明，宿主基因组因素可能导致 COVID-19 感染中的疾病反应变异性。在本文中，我们考虑宿主基因组学是否以及如何影响疫苗分配决策。探讨了三个潜在的宿主遗传因素：易感染性、抗感染性和传染性增加。我们主张在疫苗接种计划中优先考虑遗传脆弱者，并评估具有抗感染遗传标志物的个体在伦理上被优先排序的可能性。最后，我们讨论了具有增加传染性遗传标志物（更有可能传播 COVID-19 的个体）的个体的伦理优先排序。
