Pan Pan, Wang Lu, Wu Chujun, Jin Kun, Cao Song, Qiu Yan, Teng Ziwei, Li Sujuan, Shao Tiannan, Huang Jing, Wu Haishan, Xiang Hui, Chen Jindong, Liu Feng, Tang Hui, Guo Wenbin
National Clinical Research Center on Mental Disorders and Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, China.
Department of Radiology, Tianjin Medical University General Hospital, Tianjin, China.
Front Aging Neurosci. 2022 Feb 17;13:803080. doi: 10.3389/fnagi.2021.803080. eCollection 2021.
Abnormalities of functional connectivity (FC) in certain brain regions are closely related to the pathophysiology of major depressive disorder (MDD). Findings are inconsistent with different presuppositions in regions of interest. Our research focused on voxel-wise brain-wide FC changes in patients with MDD in an unbiased manner.
We examined resting-state functional MRI in 23 patients with MDD and 26 healthy controls. Imaging data were analyzed by using global-brain FC (GFC) and used to explore the correlation of abnormal GFC values with clinical variables.
Increased GFC values in the left medial superior frontal gyrus (SFGmed) and decreased GFC values in the right supplementary motor area (SMA) were observed in the patients with MDD compared with the controls. The decreased GFC values in the right SMA had a positive correlation with vitamin D and Hamilton Anxiety Scale (HAM-A) scores.
Abnormal GFC in the hate circuit, particularly increased GFC in the left SFGmed and decreased GFC in the right SMA, appears to be a new sight for comprehending the pathological alterations in MDD.
某些脑区的功能连接（FC）异常与重度抑郁症（MDD）的病理生理学密切相关。在感兴趣区域的研究结果因不同的预设而不一致。我们的研究以无偏倚的方式聚焦于MDD患者全脑体素水平的FC变化。
我们对23例MDD患者和26名健康对照者进行了静息态功能磁共振成像检查。通过全脑功能连接（GFC）分析成像数据，并用于探索异常GFC值与临床变量之间的相关性。
与对照组相比，MDD患者左侧额上回内侧（SFGmed）的GFC值升高，右侧辅助运动区（SMA）的GFC值降低。右侧SMA中降低的GFC值与维生素D和汉密尔顿焦虑量表（HAM-A）评分呈正相关。
情绪回路中异常的GFC，特别是左侧SFGmed的GFC增加和右侧SMA的GFC降低，似乎是理解MDD病理改变的一个新视角。
